Steroids

Cessation of Steroid Use

Published

13 years ago

July 15, 2012

F Kyle

Usually, professional athletes use steroids over several years without interruption. This happens because of the fact that they must always be ready for various competitions, to be in shape for different advertisements. Many amateur bodybuilders or athletes are in a similar situation. Because their success depends on their appearance, they have to use steroids whole year. However, the athletes are going to be forced to stop steroid consumption. The causes of this are very different.

The most important is a health problem. Along with these, there are other reasons like some stops using them on schedule because they heard that after 12 weeks has to do some break, other because of limited financial resources, others before doping controls. Almost all athletes, in this case, are in a state of panic.

The following weeks after steroid withdrawal athletes experience the effects of the end of steroids cycle like weight loss, the decrease in strength, fat accumulation, etc. Many athletes pass through a depression and unwilling to go further.

This happens because they enter the catabolic phase, and they will have to deal with some important problems during the next weeks. As you know the level of testosterone in the body is low, and it increase is dependent on the duration steroid use and even dose. The more androgenic the steroid is the greater is the effect of testosterone secretion cesses.

First among steroids who slow down are Testosterone, Dianabol, and Anapolon. Using moderate preparations like Deca, Primobolan, Winstrol, the scale of testosterone shrinking is not just smaller but even the shrinking itself comes later and more gradually.

In case of use of Dianabol, studies have shown that a relatively conservative dose of 20 mg daily after 10 days personal hormone secretion diminishes to 30-40%. Because the body cannot pick up within a day the level of personal hormone secretion, the athlete enters the critical phase of transition. Already the action of exogenous hormones doesn’t appear and the law level testosterone doesn’t improve the situation. It is, therefore, necessary as soon as possible to increase testosterone level.

The second problem is the loss of results gained during the steroids use. As we said above, steroids have a potent anti-catabolic effect. The body reacts to this fact with a large amount of cortisol secretion, as the last which is in the blood can finally achieve their goal.

And this is not so dangerous if the athlete uses steroids permanently, but as steroid use is discontinued, receptor again becomes free for cortisol molecules. They rush suddenly on receptors, forming a complex "receptor molecule" and wears a sad enough information for muscle tissue: decomposition of amino acids.

So, the second problem together with the secretion of high testosterone levels is the shrink of cortisol level.

Further, we will describe the period of transition which play the key factor when it comes to the withdrawal of steroids use.and current level of knowledge possible. Want to notice that this information can not guarantee that the athlete will not lose anything obtained.

So, first of all, is every person should determine advance when the break of steroids will occur and to prepare in advance for this. This involves purchasing the necessary maintenance preparations and also finding the correct psychological support for possible shrinking of muscles and strength volumes.

Train to that day slowly and plan. Approximately 4 weeks before the athlete should minimize the amount of steroid dose and strong androgen action. If you are on pills like Dianabol and Anapolon, then decrease gradually and slowly their number within 14 days, so the use of androgenic steroid pills to be finished 2 weeks before the “big” day.

Those who used injectable steroids such as androgen Testosterone or Parabolan reduce dose injections to 0 within 4 weeks, so that their use be stopped only in that day. Use of steroids with moderate effects, such as oral Primobolan, Winstrol or Oxandrolone have to be stopped slowly during 14 days before the day you give up the use of steroids.

Must Read: Golden Rules of Steroids Use

Avoid sudden cessation of all types of steroid use simultaneously. Because of this body swerves the catabolic phase immediately. Cortisol receptors become free and combined with low testosterone levels lead to considerable loss of strength and muscle mass, fat and water accumulation.

Also, appear especially sudden unwillingness of training and lack of sexual interest and also a terrible mood of the athlete. If you have to use steroids because of health, they never stop the use of preparations simultaneously.

So, keep in mind that muscles gained as result of steroid use can be kept as follows:

Adapt your nutrition to changed circumstances. At the end of steroid use, the metabolism normalizes. This means that the athlete should minimize the number of calories daily over several days. But protein consumption is kept still quite high - at least 3 g per 1 kg of body weight.
Decrease the number of workouts. Avoid the same program that you used when you use steroids because otherwise, the catabolic state will worsen. It’s absolutely contraindicated to try to keep the muscles expanded via intensive training, whereas it is a harmful way. Limit yourself to use basic exercises, train each muscle once a week and strive to maintain your strength. Train only three, four times a week, duration of training should be no longer 75 minutes.

Experience has shown that with discipline and strength of character it possible to reduce significantly the loss of muscle mass after ending a steroids cycle. Also, along with steroids cycle, the same important have the periods between them. The abler you are to manage this period efficiently and the right way, the bigger our chances to maintain your muscle mass. Since there are many people able to increase muscle mass during a steroid cycle, but too few those who know how to keep it between cycles.

Must Read: How Much of Weight You Lose After Ending a Steroid Cycle

In addition to using steroids, passing between classes is the possible only possibility of permanent upgrades. Often have to give up once and then make two steps forward. This is an essential fact and therefore cannot ignore it and you can not do anything. Many are able to increase their muscle mass with steroids, but in preserving and maintaining it after, few are able.

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F Kyle

The "GYMRAT" of this blog, Pro-blogger and Fitness Instructor since 2008

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Steroids

Decoding IGF-1 LR3: A Guide to its Benefits

Published

3 days ago

April 25, 2025

Sane

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a synthetic variant of IGF-1, a hormone produced by the liver in response to growth hormone (GH). Unlike GH, which works indirectly, IGF-1 directly facilitates the growth and repair of muscle cells.

Related Article: Ostarine for Beginners; The Ultimate Guide

This modified version of IGF-1 is engineered to avoid binding with IGF-binding proteins, extending its half-life to 20–30 hours. As a result, it remains active in the body significantly longer than natural IGF-1.

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Many performance athletes incorporate IGF-1 LR3 post-workout to enhance muscle growth, speed up recovery, and support fat loss. When injected into specific muscle groups, it often produces localized effects. Additionally, it helps with nutrient distribution and, in some cases, improves insulin sensitivity.

On the other hand, human growth hormone (HGH) operates more broadly and indirectly, stimulating the liver to produce IGF-1 and offering more systemic benefits such as improved skin health, joint support, and fat reduction, albeit at a slower pace.

Typical IGF-1 LR3 doses range from 20–50 mcg daily, administered subcutaneously or intramuscularly, often following a workout.

Key Features of IGF-1 LR3

Enhanced Bioavailability: It avoids binding with IGF-binding proteins, increasing its potency.

Muscle Growth & Repair: Directly stimulates muscle cell proliferation and differentiation.

Improved Nutrient Distribution: Helps shuttle nutrients into muscle cells, supporting recovery.

Potential Fat Loss Benefits: Some users report improved insulin sensitivity and fat metabolism.

Mechanism of Action

IGF-1 LR3 interacts with IGF-1 receptors on muscle cells, activating pathways like PI3K-AKT and MAPK, which are crucial for cell growth and regeneration. This makes it a powerful tool for bodybuilders and athletes looking to optimize recovery and muscle development.

What Are the Top 10 Alternatives to IGF-1 LR3?

Here are some of the top alternatives to IGF-1 LR3, each with unique benefits for muscle growth, recovery, and performance:

BPC-157 – Known for its regenerative properties, it enhances healing and tissue repair.

CJC-1295 – A growth hormone-releasing peptide that boosts GH levels for muscle development.

Ipamorelin – Stimulates GH release with minimal side effects, making it a safer option.

MK-677 (Ibutamoren) – A potent GH secretagogue that promotes muscle growth and fat loss.

Sermorelin – Encourages natural GH production, supporting recovery and lean muscle gains.

Tesamorelin – Primarily used for fat loss, but also aids in muscle preservation.

Follistatin-344 – Inhibits myostatin, allowing for increased muscle hypertrophy.

PEG-MGF (Pegylated Mechano Growth Factor) – Enhances muscle repair and growth post-exercise.

GHRP-6 – Stimulates appetite and GH release, supporting muscle mass gains.

GHRP-2 – Similar to GHRP-6 but with fewer hunger-related side effects.

Each of these peptides has distinct mechanisms and benefits.

Must Read: Are Nootropics a Better Option to AAS?

Potential Risks Associated With IGF-1 LR3

IGF-1 LR3 comes with several potential risks, especially for bodybuilders using it to enhance muscle growth. Here are some key concerns:

Hypoglycemia (Low Blood Sugar) – IGF-1 LR3 increases glucose uptake in muscle cells, which can lead to dangerously low blood sugar levels if not managed properly.

Organ Growth – Since IGF-1 affects all tissues, excessive use may lead to unwanted growth in organs, increasing health risks.

Cancer Risk – IGF-1 plays a role in cell proliferation, and elevated levels have been linked to an increased risk of certain cancers.

Water Retention & Edema – Some users experience bloating and fluid retention, which can affect performance and aesthetics.

Joint Pain & Stiffness – Excessive IGF-1 levels may contribute to joint discomfort due to increased tissue growth.

Cardiovascular Issues – There is some concern that IGF-1 LR3 could contribute to heart enlargement or other cardiovascular complications.

Desensitization – Long-term use may reduce the body's natural IGF-1 production, leading to dependency

Overall

IGF-1 LR3's ability to bypass IGF-binding proteins makes it more potent but also increases the likelihood of desensitization with prolonged use. For those considering it, careful dosing and monitoring are crucial to mitigate side effects.

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Steroids

AOD-9604: The Fat-Burning Peptide Explained

Published

3 weeks ago

April 9, 2025

Sane

AOD-9604, along with the similar HGH Frag 176-191, is a peptide derived from Growth Hormone that includes only the amino acids in HGH responsible for stimulating fat breakdown, known as lipolysis.

This means that these peptides offer the fat-burning benefits of HGH without its other effects—whether beneficial or adverse—and come at a lower cost.

Related Article: Anavar Cycle for Men and Women

Lipolysis refers to the process where fat cells are broken down to be utilized as energy. AOD-9604 promotes accelerated fat loss by increasing the body's use of fat as fuel.

For optimal results, the peptides should be used in a fasted state. AOD-9604 and Frag 176-191 are most effective when administered at a dose of 125-250mcg before bedtime (at least 3-4 hours after eating) and in the morning at the same dose, followed by a fasting period of 3-4 hours, ideally combined with fasted cardio.

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Similar Peptides with Fat-Burning Effect

Here’s a list of 10 peptides similar to AOD-9604, each with a brief description:

Ipamorelin: A growth hormone-releasing peptide (GHRP) that stimulates the natural release of growth hormone, promoting fat loss, muscle growth, and improved recovery without affecting other hormones like cortisol or prolactin.

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CJC-1295: A peptide that increases growth hormone and IGF-1 levels, aiding in fat loss, muscle gain, and improved sleep quality. It has a long half-life, making it convenient for users.

HGH Frag 176-191: A fragment of human growth hormone specifically designed for fat-burning. It targets adipose tissue without the broader effects of full-length HGH.

Tesamorelin: Known for reducing visceral fat, this peptide stimulates the release of growth hormone and is often used for weight management and metabolic health.

BPC-157: While primarily known for healing and recovery, BPC-157 can support fat loss indirectly by improving gut health and reducing inflammation.

Melanotan II: Originally developed for skin tanning, it also has appetite-suppressing properties, making it useful for weight management.

Thymosin Beta-4 (TB-500): Focused on healing and recovery, it can enhance physical performance and indirectly support fat loss through improved activity levels.

GHRP-6: A growth hormone-releasing peptide that boosts appetite and metabolism, aiding in muscle growth and fat loss.

Semaglutide: A GLP-1 receptor agonist that regulates appetite and blood sugar levels, making it effective for weight loss and metabolic health.

MK-677 (Ibutamoren): A growth hormone secretagogue that increases growth hormone and IGF-1 levels, promoting fat loss, muscle gain, and improved recovery.

List of Peptides With a Counteractive Effect Bodybuilders Must Avoid

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Some peptides can inadvertently lead to fat gain due to their effects on metabolism and appetite regulation. Here are a few that bodybuilders might want to avoid or use cautiously:

GHRP-6 – While it stimulates growth hormone release, it also significantly increases appetite, which can lead to excess calorie consumption and fat gain.
IGF-1 LR3 – This peptide enhances muscle growth but can also promote fat storage if not carefully managed with diet and training.
MK-677 (Ibutamoren) – Though technically a growth hormone secretagogue rather than a peptide, it boosts GH levels but often leads to increased hunger and potential fat accumulation.
CJC-1295 with DAC – While effective for muscle growth, its prolonged GH release can sometimes lead to unwanted fat retention if not paired with a strict diet

Overall

AOD-9604, derived from Growth Hormone, stimulates fat-burning by targeting lipolysis—the breakdown of fat for energy. It delivers these benefits without the additional effects of Growth Hormone, making it more cost-effective. For maximum effectiveness, it should be administered in a fasted state, ideally before bed and again in the morning at 125-250mcg doses. Pairing its use with fasting and fasted cardio can further enhance fat loss. Its sole focus is on improving the body’s ability to burn fat efficiently.

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Bodybuilding

Understanding Trenbolone-Induced Cough (“Tren Cough”)

Published

3 weeks ago

April 7, 2025

Sane

Trenbolone, a potent anabolic steroid, can sometimes cause “tren cough”—a sudden and intense coughing episode shortly after injection. Although not exclusive to Trenbolone, it is more commonly associated with this substance due to its highly irritant nature.

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Mechanisms Behind Tren Cough

Solvent and Carrier Irritation

Trenbolone formulations often include volatile solvents like benzyl alcohol or benzyl benzoate, which may irritate lung tissues when absorbed quickly into systemic circulation.

Prostaglandin Release

Trenbolone promotes increased production of prostaglandins, particularly PGF2α. This compound triggers contraction in the smooth muscles of the lungs, leading to bronchoconstriction and coughing.

Micro-Oil Embolism

Tiny oil droplets from an injection can reach capillaries and travel to the lungs, causing mild embolic reactions that lead to temporary oxygen deprivation and coughing.

Histamine and Mast Cell Activation

For some individuals, Trenbolone triggers histamine release and mast cell activation, mimicking an allergic response and causing bronchospasms and cough reflexes.

Related Article: Best Syringes for Steroid Injection on Amazon

Using Salbutamol (Albuterol) to Manage Tren Cough

Salbutamol, a widely-used β2-adrenergic receptor agonist, can alleviate tren cough symptoms by:
Relaxing bronchial muscles, easing spasms that cause coughing.
Inhibiting prostaglandin effects, reducing bronchoconstriction associated with PGF2α.
Opening airways, preventing severe respiratory restrictions in susceptible individuals.

Application Methods

Inhaler (Optimal)

Take 1–2 puffs of salbutamol (100–200 mcg) 5–10 minutes before a Trenbolone injection. If coughing occurs afterward, additional puffs can swiftly resolve the issue.

Oral Tablets (Moderate)

Consuming 2–4 mg tablets 30–60 minutes before injection offers slower, longer-lasting relief but may be less effective than inhalation methods.

Nebulizer (Severe Cases)

For individuals with frequent episodes, nebulized doses of 2.5 mg salbutamol can provide substantial relief.

Preventive Measures to Reduce Tren Cough Risk

Inject slowly to minimize systemic absorption and irritant effects.
Split doses to lower reaction severity with smaller quantities.
Opt for ventrogluteal injection sites, which have fewer blood vessels, reducing oil embolism risk.
Choose lower-concentration solutions to lessen irritation, as higher concentrations (e.g., Tren Ace 200 mg/ml) are more likely to provoke reactions.

What Other Steroids Can Induce Coughing?

Here's a curated list of peptides, SARMs, and PEDs that may potentially cause coughing or respiratory irritation in bodybuilders and fitness enthusiasts:

Peptides

IGF-1 LR3 (Insulin-like Growth Factor): Known for its anabolic effects, IGF-1 LR3 can occasionally cause mild respiratory irritation due to systemic absorption.

TB-500 (Thymosin Beta-4): While rare, improper injection techniques or high doses may lead to transient coughing episodes.

GHRP-6 (Growth Hormone-Releasing Peptide): This peptide can stimulate histamine release, potentially leading to bronchospasms and coughing.

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SARMs (Selective Androgen Receptor Modulators)

RAD-140: (Testolone) Some users report throat irritation or coughing, often attributed to solvents used in liquid formulations.

YK-11: Known for its myostatin-inhibiting properties, YK-11 may cause mild respiratory discomfort in sensitive individuals.

LGD-4033 (Ligandrol): Though uncommon, some users experience coughing due to carrier solvents or allergic-like reactions.

PEDs (Performance-Enhancing Drugs)

Boldenone Undecylenate (Equipoise): This injectable steroid can cause “Equipoise cough,” similar to tren cough, due to oil embolism or irritant solvents.

Testosterone Suspension: The water-based formulation may lead to coughing episodes if injected improperly or absorbed rapidly.

Nandrolone Decanoate (Deca-Durabolin): While less common, coughing can occur due to histamine release or systemic irritation.

More Tips to Minimize Coughing Risks

Use proper injection techniques to avoid embolic reactions.
Opt for lower-concentration solutions to reduce irritant effects.
Consider antihistamines or bronchodilators for individuals prone to respiratory sensitivity.

Are There Alternatives to Cough-inducing Steroids?

Here are some alternatives to cough-inducing steroids that can provide similar anabolic effects while minimizing respiratory irritation:

Peptides

IGF-1 LR3 (Insulin-like Growth Factor)

Promotes muscle growth and recovery without the irritant properties of certain steroids.

TB-500 (Thymosin Beta-4)

Enhances tissue repair and reduces inflammation, making it a safer option for recovery.

BPC-157 (Body Protection Compound)

Known for its healing properties, it supports muscle repair and joint health.

SARMs (Selective Androgen Receptor Modulators)

RAD-140 (Testolone)

Provides significant muscle-building effects with fewer systemic side effects compared to traditional steroids.

LGD-4033 (Ligandrol)

Boosts lean muscle mass and strength without the risk of respiratory irritation.

MK-677 (Ibutamoren)

Stimulates growth hormone release, aiding in muscle growth and recovery.

Natural Alternatives

Turkesterone

A plant-based ecdysteroid that supports muscle protein synthesis and recovery.

Ecdysterone

Another natural compound that mimics anabolic effects without the harsh side effects.

Creatine Monohydrate

Enhances strength and muscle mass through improved energy production during workouts.

Other Options

Human Growth Hormone (HGH)

Promotes muscle growth and fat loss, though it requires careful monitoring due to potential side effects.

Testosterone Boosters

Natural supplements like D-Aspartic Acid or Tribulus Terrestris can help optimize testosterone levels for muscle growth.

SARMs Alternatives

Legal and safer versions of SARMs are available, offering similar benefits without the risks associated with traditional SARMs.

Overall

We have explored the phenomenon of "tren cough," a sudden, intense coughing episode often caused by Trenbolone injections due to factors like solvent irritation, prostaglandin release, micro-oil embolism, or histamine activation. Preventive measures such as using salbutamol (via inhaler, oral tablets, or nebulizer), injecting slowly, splitting doses, and opting for lower-concentration solutions were highlighted.

Additionally, alternative compounds to tren cough-inducing steroids were discussed, including peptides like IGF-1 LR3 and TB-500, SARMs such as RAD-140 and LGD-4033, and natural options like Turkesterone, ecdysterone, and creatine. These alternatives provide anabolic effects while minimizing respiratory side effects. The conversation also underscored the importance of proper injection techniques and thoughtful compound selection to reduce risks.

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