Steroids

Steroids and Bodybuilders: How are Steroids Abused?

Published

13 years ago

November 24, 2011

F Kyle

etesAthlSteroids use among athletes has become widespread in recent years. These are synthetic substances that can effectively and quickly reduce swelling and pain. It is related to cortisol, a hormone produced by the cortex of the adrenal glands. We can divide steroids into two groups. One is corticosteroids, mainly used for medical purposes like arthritis treatment, as their anti-inflammatory effects are remarkable.

Steroids are a class of drugs commonly abused by bodybuilders to enhance their performance and physical appearance.

While steroids can be used safely under the guidance of a physician, they are often abused to gain an edge over opponents. When abused, anabolics can have serious health consequences, including an increased risk of heart attack, stroke, liver damage, and even death.

This article will explore how steroids are abused and the potential health risks associated with steroid abuse.

Steroids Use: Mechanism of Action

Steroids stimulate the body's anabolic (building) hormones and inhibit the body's catabolic (breaking down) hormones. In other words, steroids are a chemical form of anabolic and catabolic steroids. However, their mechanism of action is not well understood.

By now, you know that steroids are a class of drugs designed to mimic the effects of hormones naturally produced by the body. While they can be beneficial when used in the proper context, they can also have serious side effects when abused.

Let us explore how steroids chemically affect the body and what potential risks may be associated with their use. We will look at how steroids interact with hormones, proteins, and other bodily molecules to produce their desired effects.

By understanding these chemical interactions, we can understand why steroids should only be used under medical supervision.

Anabolics can alter the hormonal environment in the body. Inherently, they have a strong binding affinity for androgen receptors inside cells. They can be classified as either anabolic or androgenic steroids.

The terms are often interchanged in a common language, but there is an essential distinction between them. As mentioned, steroids are hormones that provide growth-promoting effects to muscles. Androgens promote masculine features like facial hair growth, fat distribution throughout the body, and prostate enlargement.

Anabolic Steroids vs. Androgens

Steroids and Androgens are two different types of drugs that have been used for decades to increase muscle mass and strength. While both have their unique benefits, it is crucial to understand their differences.

Anabolic Steroids can be taken orally or injected into the body, while Androgens are naturally occurring hormones found in the body. Both drugs can help increase muscle mass, but they do so differently. In this article, we will explore the differences between Anabolic Steroids and Androgens and how they can each be used effectively in bodybuilding.

What are Anabolic Steroids? Anabolic Steroids are synthetic hormones that can be used to build muscle and stimulate the body's natural production of testosterone.

The following drugs have been classified as Anabolics: Androstenedione, Stanozolol, Testosterone, Dianabol (methasterone), Methandrostenolone, Oxymetholone, and Stenbolone.

In non-human animals, anabolic steroids usually refer to the male sex hormone testosterone and its derivatives. The most well-known of these is testosterone itself.

Some examples of common anabolic steroids include Boldenone, Clenbuterol, Epitestosterone (17a-methyl-androst-4-ene), Fluoxymesterone, Mesterolone, Methandienone (methandrostenolone), Nandrolone, Oxymethalone.

Abbreviations used in this program include :

ADN = Androgenic Dihydrotestosteron

DHT = Dihydrotestosterone /androstendione/10-dihydrotestosterone/androstenone/NandroloneEnantate = 1-Methyl enanthateEtiocholanolone = 5-oxo-testosteroneEtiocholanolone can also be called "17b-(hydroxymethyl)-5a-androstan-3,17b-diol"Methasteron (Dianabol) = Methasteride (17α,21β)-7α,17α,21β androstanediol acetate; methyl clostebol acetate, among others.

Steroids Uses and Benefits

Anabolics are hormones produced in the body, primarily by the adrenal glands. They bind to androgen receptors in cells to exert their effects, including increased appetite, muscle growth, and bone density.

Although serious health risks are associated with anabolic steroids, some potential health benefits are realized by using them. For example, anabolic steroids may reduce the risk of osteoporosis and improve bone density.

Some studies have found that testosterone therapy may increase lean muscle mass, strength, and exercise capacity in people with Alzheimer's. This is thought to occur because these drugs lower testosterone levels in the brain, which may increase the hormone levels that stimulate muscle growth.

They are commonly used to reduce inflammation, stimulate muscle growth, and suppress the immune system.

It is also used in treating AIDS as it helps put on weight and improves the muscles. The other is anabolic steroids. Those are used as performance-enhancing drugs. In many states of America, steroids are illegal.

There are some medicines in which these steroids are used, but they are allowed only under the prescription of specialists.

Must Read: When Were Steroids Banned?

Why Steroids Are Banned In Some Instances

Some anabolics can cause serious health problems when misused or too long. This is why some instances have banned their use altogether.

In this section, we will discuss why steroids are banned in some instances and the potential health risks associated with them. We will also examine the potential benefits of using steroids in a controlled and monitored environment.

Finally, we will explore the ethical implications of steroid use and how it affects athletes and society.

Why Steroids are Banned?

The most common reason anabolics are banned is that they can cause serious health problems when misused or for too long. The drug’s ability to perform at a high level and maintain muscle mass can mask the user’s general health and physical capabilities.

These drugs have been linked to cardiac events, liver failure, brain damage, and seizures. In addition to the potential health risks associated with steroid use, their usage may be illegal in some instances based on the number of times they were abused or prohibited from being used as part of any sporting event.

Steroids are often banned for competitive sports, as they can result in unfair and fraudulent advantages. If a third party can manipulate the drug’s usage and obtain an unfair advantage in sporting competitions, it undermines the integrity of an event.

They are, in fact, corticosteroids. Anabolics are strictly banned in many entries because of their side effects on the users' health. Almost all steroids are banned, even when used in many countries, including all developed countries.

Now the question arises of how these steroids are abused. The answer is quite apparent. Some steroids are taken orally; some are injected intramuscularly; still, some steroids are in the form of gel and are applied to the skin to get the desired results.

Ways Steroids Are Misused By Athletes

It is viewed that the people who are guilty of steroid abuse use this drug 10 to 100 times higher in dose than the dose prescribed by the doctors. They do this only because they desire to excel and gain an edge in their field. also want to improve their physique and increase efficiency by taking these drugs. They commonly use this drug in three ways.

Cycling:

People usually use these steroids in cycles. They begin with the administration of low dosage at regular intervals. Then multiply, and the high dose of anabolics is taken over a specific period, stopped for a particular period, and then started again to carry on the cycle.

Must Read: Cheapest and Safest Method of Cycling Steroids

The users of this method believe that in this way, they do not have the worst effects. They think that using drugs off and on does not affect the body's natural function, and in this way, they are at low risk.

Stacking:

Must Read: The Best Mild Steroid -With Proper Dosage And Stacking Examples

In this steroid method, people combine two or more drugs to affect their bodies differently. It can be a tablet with some injection or a dose with short-effects ECT with long-term consequences. This theory does not have scientific proof. Even then, it is trendy among ordinary people.

Pyramiding:

In this method, abusers do not take higher doses in the beginning. They gradually increase the amount and frequency of the amount. When they reach the mid-cycle peak, they taper it down by taking it to zero.

The worst thing about these steroids is that they increase your appetite to get more and more drugs until you reach a point of no return.

Ethical Implications of Steroid Use

Steroid use is a controversial topic that has been debated for years. The ethical implications of steroid use are complex and far-reaching, with potential implications for athletes, medical professionals, and society.

Stakeholders are still exploring the ethical implications of their use from different perspectives to provide an in-depth understanding of the issue. From the potential health risks to the societal impact, this paper will examine the ethical considerations associated with steroid use and discuss potential solutions to mitigate these issues.

Athletes face many health risks when using steroids, including emotional issues such as depression and anxiety. Athletes have been banned from steroid use in professional and amateur sports leagues across the globe.

Take Away

Athletes have been banned from steroid use in both professional and amateur sports leagues across the globe. However, there is some debate about the effectiveness of these bans in protecting athletes from future health complications due to their steroid use.

While banning may seem like a productive measure in reducing the risk factor associated with certain substances, it does not eliminate this risk. One of the biggest risks that athletes face is developing a substance addiction. If an athlete uses steroids long enough and frequently enough, they may develop a dependence on these drugs. This can lead to an inability to stop using them despite their negative effects on their health.

Without treating this dependency, athletes are subject to life-threatening consequences such as overdose or death due to misuse of these drugs.

Must Read: What You Have To Know About Pyramiding Steroids Doses In Different Cycles

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F Kyle

The "GYMRAT" of this blog, Pro-blogger and Fitness Instructor since 2008

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Steroids

AOD-9604: The Fat-Burning Peptide Explained

Published

2 weeks ago

April 9, 2025

Sane

AOD-9604, along with the similar HGH Frag 176-191, is a peptide derived from Growth Hormone that includes only the amino acids in HGH responsible for stimulating fat breakdown, known as lipolysis.

This means that these peptides offer the fat-burning benefits of HGH without its other effects—whether beneficial or adverse—and come at a lower cost.

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Lipolysis refers to the process where fat cells are broken down to be utilized as energy. AOD-9604 promotes accelerated fat loss by increasing the body's use of fat as fuel.

For optimal results, the peptides should be used in a fasted state. AOD-9604 and Frag 176-191 are most effective when administered at a dose of 125-250mcg before bedtime (at least 3-4 hours after eating) and in the morning at the same dose, followed by a fasting period of 3-4 hours, ideally combined with fasted cardio.

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Similar Peptides with Fat-Burning Effect

Here’s a list of 10 peptides similar to AOD-9604, each with a brief description:

Ipamorelin: A growth hormone-releasing peptide (GHRP) that stimulates the natural release of growth hormone, promoting fat loss, muscle growth, and improved recovery without affecting other hormones like cortisol or prolactin.

CJC-1295: A peptide that increases growth hormone and IGF-1 levels, aiding in fat loss, muscle gain, and improved sleep quality. It has a long half-life, making it convenient for users.

HGH Frag 176-191: A fragment of human growth hormone specifically designed for fat-burning. It targets adipose tissue without the broader effects of full-length HGH.

Tesamorelin: Known for reducing visceral fat, this peptide stimulates the release of growth hormone and is often used for weight management and metabolic health.

BPC-157: While primarily known for healing and recovery, BPC-157 can support fat loss indirectly by improving gut health and reducing inflammation.

Melanotan II: Originally developed for skin tanning, it also has appetite-suppressing properties, making it useful for weight management.

Thymosin Beta-4 (TB-500): Focused on healing and recovery, it can enhance physical performance and indirectly support fat loss through improved activity levels.

GHRP-6: A growth hormone-releasing peptide that boosts appetite and metabolism, aiding in muscle growth and fat loss.

Semaglutide: A GLP-1 receptor agonist that regulates appetite and blood sugar levels, making it effective for weight loss and metabolic health.

MK-677 (Ibutamoren): A growth hormone secretagogue that increases growth hormone and IGF-1 levels, promoting fat loss, muscle gain, and improved recovery.

List of Peptides With a Counteractive Effect Bodybuilders Must Avoid

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Some peptides can inadvertently lead to fat gain due to their effects on metabolism and appetite regulation. Here are a few that bodybuilders might want to avoid or use cautiously:

GHRP-6 – While it stimulates growth hormone release, it also significantly increases appetite, which can lead to excess calorie consumption and fat gain.
IGF-1 LR3 – This peptide enhances muscle growth but can also promote fat storage if not carefully managed with diet and training.
MK-677 (Ibutamoren) – Though technically a growth hormone secretagogue rather than a peptide, it boosts GH levels but often leads to increased hunger and potential fat accumulation.
CJC-1295 with DAC – While effective for muscle growth, its prolonged GH release can sometimes lead to unwanted fat retention if not paired with a strict diet

Overall

AOD-9604, derived from Growth Hormone, stimulates fat-burning by targeting lipolysis—the breakdown of fat for energy. It delivers these benefits without the additional effects of Growth Hormone, making it more cost-effective. For maximum effectiveness, it should be administered in a fasted state, ideally before bed and again in the morning at 125-250mcg doses. Pairing its use with fasting and fasted cardio can further enhance fat loss. Its sole focus is on improving the body’s ability to burn fat efficiently.

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Understanding Trenbolone-Induced Cough (“Tren Cough”)

Published

3 weeks ago

April 7, 2025

Sane

Trenbolone, a potent anabolic steroid, can sometimes cause “tren cough”—a sudden and intense coughing episode shortly after injection. Although not exclusive to Trenbolone, it is more commonly associated with this substance due to its highly irritant nature.

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Mechanisms Behind Tren Cough

Solvent and Carrier Irritation

Trenbolone formulations often include volatile solvents like benzyl alcohol or benzyl benzoate, which may irritate lung tissues when absorbed quickly into systemic circulation.

Prostaglandin Release

Trenbolone promotes increased production of prostaglandins, particularly PGF2α. This compound triggers contraction in the smooth muscles of the lungs, leading to bronchoconstriction and coughing.

Micro-Oil Embolism

Tiny oil droplets from an injection can reach capillaries and travel to the lungs, causing mild embolic reactions that lead to temporary oxygen deprivation and coughing.

Histamine and Mast Cell Activation

For some individuals, Trenbolone triggers histamine release and mast cell activation, mimicking an allergic response and causing bronchospasms and cough reflexes.

Related Article: Best Syringes for Steroid Injection on Amazon

Using Salbutamol (Albuterol) to Manage Tren Cough

Salbutamol, a widely-used β2-adrenergic receptor agonist, can alleviate tren cough symptoms by:
Relaxing bronchial muscles, easing spasms that cause coughing.
Inhibiting prostaglandin effects, reducing bronchoconstriction associated with PGF2α.
Opening airways, preventing severe respiratory restrictions in susceptible individuals.

Application Methods

Inhaler (Optimal)

Take 1–2 puffs of salbutamol (100–200 mcg) 5–10 minutes before a Trenbolone injection. If coughing occurs afterward, additional puffs can swiftly resolve the issue.

Oral Tablets (Moderate)

Consuming 2–4 mg tablets 30–60 minutes before injection offers slower, longer-lasting relief but may be less effective than inhalation methods.

Nebulizer (Severe Cases)

For individuals with frequent episodes, nebulized doses of 2.5 mg salbutamol can provide substantial relief.

Preventive Measures to Reduce Tren Cough Risk

Inject slowly to minimize systemic absorption and irritant effects.
Split doses to lower reaction severity with smaller quantities.
Opt for ventrogluteal injection sites, which have fewer blood vessels, reducing oil embolism risk.
Choose lower-concentration solutions to lessen irritation, as higher concentrations (e.g., Tren Ace 200 mg/ml) are more likely to provoke reactions.

What Other Steroids Can Induce Coughing?

Here's a curated list of peptides, SARMs, and PEDs that may potentially cause coughing or respiratory irritation in bodybuilders and fitness enthusiasts:

Peptides

IGF-1 LR3 (Insulin-like Growth Factor): Known for its anabolic effects, IGF-1 LR3 can occasionally cause mild respiratory irritation due to systemic absorption.

TB-500 (Thymosin Beta-4): While rare, improper injection techniques or high doses may lead to transient coughing episodes.

GHRP-6 (Growth Hormone-Releasing Peptide): This peptide can stimulate histamine release, potentially leading to bronchospasms and coughing.

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SARMs (Selective Androgen Receptor Modulators)

RAD-140: (Testolone) Some users report throat irritation or coughing, often attributed to solvents used in liquid formulations.

YK-11: Known for its myostatin-inhibiting properties, YK-11 may cause mild respiratory discomfort in sensitive individuals.

LGD-4033 (Ligandrol): Though uncommon, some users experience coughing due to carrier solvents or allergic-like reactions.

PEDs (Performance-Enhancing Drugs)

Boldenone Undecylenate (Equipoise): This injectable steroid can cause “Equipoise cough,” similar to tren cough, due to oil embolism or irritant solvents.

Testosterone Suspension: The water-based formulation may lead to coughing episodes if injected improperly or absorbed rapidly.

Nandrolone Decanoate (Deca-Durabolin): While less common, coughing can occur due to histamine release or systemic irritation.

More Tips to Minimize Coughing Risks

Use proper injection techniques to avoid embolic reactions.
Opt for lower-concentration solutions to reduce irritant effects.
Consider antihistamines or bronchodilators for individuals prone to respiratory sensitivity.

Are There Alternatives to Cough-inducing Steroids?

Here are some alternatives to cough-inducing steroids that can provide similar anabolic effects while minimizing respiratory irritation:

Peptides

IGF-1 LR3 (Insulin-like Growth Factor)

Promotes muscle growth and recovery without the irritant properties of certain steroids.

TB-500 (Thymosin Beta-4)

Enhances tissue repair and reduces inflammation, making it a safer option for recovery.

BPC-157 (Body Protection Compound)

Known for its healing properties, it supports muscle repair and joint health.

SARMs (Selective Androgen Receptor Modulators)

RAD-140 (Testolone)

Provides significant muscle-building effects with fewer systemic side effects compared to traditional steroids.

LGD-4033 (Ligandrol)

Boosts lean muscle mass and strength without the risk of respiratory irritation.

MK-677 (Ibutamoren)

Stimulates growth hormone release, aiding in muscle growth and recovery.

Natural Alternatives

Turkesterone

A plant-based ecdysteroid that supports muscle protein synthesis and recovery.

Ecdysterone

Another natural compound that mimics anabolic effects without the harsh side effects.

Creatine Monohydrate

Enhances strength and muscle mass through improved energy production during workouts.

Other Options

Human Growth Hormone (HGH)

Promotes muscle growth and fat loss, though it requires careful monitoring due to potential side effects.

Testosterone Boosters

Natural supplements like D-Aspartic Acid or Tribulus Terrestris can help optimize testosterone levels for muscle growth.

SARMs Alternatives

Legal and safer versions of SARMs are available, offering similar benefits without the risks associated with traditional SARMs.

Overall

We have explored the phenomenon of "tren cough," a sudden, intense coughing episode often caused by Trenbolone injections due to factors like solvent irritation, prostaglandin release, micro-oil embolism, or histamine activation. Preventive measures such as using salbutamol (via inhaler, oral tablets, or nebulizer), injecting slowly, splitting doses, and opting for lower-concentration solutions were highlighted.

Additionally, alternative compounds to tren cough-inducing steroids were discussed, including peptides like IGF-1 LR3 and TB-500, SARMs such as RAD-140 and LGD-4033, and natural options like Turkesterone, ecdysterone, and creatine. These alternatives provide anabolic effects while minimizing respiratory side effects. The conversation also underscored the importance of proper injection techniques and thoughtful compound selection to reduce risks.

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Steroids

Creatine vs Myostatin: An Expert’s Analysis

Published

1 month ago

March 20, 2025

Sane

Myostatin, a protein encoded by the MSTN gene, acts as a regulator of muscle growth. High levels of myostatin limit the body's ability to build muscle, effectively putting a cap on potential hypertrophy. Inhibiting myostatin has become a focal point for bodybuilders looking to break through plateaus and achieve significant muscle gains. The question is: can creatine, a popular and widely available supplement, help in this regard?

Medical History of Myostatin and Creatine

Myostatin and creatine, while popular now in the bodybuilding world, have their roots in entirely different contexts:

Myostatin: Natural Muscle Growth Regulator

Myostatin is a protein originally identified for its role in regulating skeletal muscle mass. In nature, it serves an evolutionary purpose: by limiting muscle growth, it conserves energy, ensuring that animals (and humans) don’t expend unnecessary resources maintaining excessive muscle tissue. This was especially important in the wild, where energy efficiency could mean the difference between survival and extinction.

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In the medical field, research into myostatin has focused on its role in muscle-wasting diseases. Scientists are exploring ways to inhibit myostatin to treat conditions like muscular dystrophy, where excessive muscle loss impairs quality of life. This therapeutic potential is where the idea of myostatin inhibition first began—long before bodybuilders latched onto the concept.

Creatine: Energy and Medical Applications

Creatine was originally studied for its role in energy metabolism. It’s a naturally occurring compound stored in muscle cells and plays a critical part in replenishing ATP (adenosine triphosphate), the body’s primary energy currency during short, high-intensity activities.

Before becoming a bodybuilding staple, creatine gained recognition in medical and sports science for its ability to improve athletic performance and assist with recovery. Furthermore, in medicine, creatine was investigated for neurological conditions such as Parkinson’s disease, Huntington’s disease, and muscular dystrophy, given its potential to improve muscle function and brain energy metabolism.

In the sports world, it was initially adopted by sprinters and weightlifters in the 1970s and 1980s for its energy-enhancing benefits.

Both myostatin and creatine have found new life in bodybuilding circles, demonstrating how discoveries in natural physiology and medical science can lead to transformative applications in fitness.

Benefits of Creatine as a Myostatin Inhibitor

Muscle Growth Potential: Research suggests that creatine, when paired with intense resistance training, may inhibit myostatin to a degree, fostering an environment for enhanced muscle growth.

Improved Exercise Performance: Creatine is well-known for its ability to increase ATP production, translating to better performance during high-intensity activities.

Versatility Across Fitness Levels

Whether you're a beginner or an advanced athlete, creatine offers benefits that complement various stages of muscle-building.

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Affordability and Accessibility

Compared to specialized myostatin inhibitors like YK-11 and ACE-031, creatine is significantly more affordable and accessible.

Side Effects of Creatine

While generally safe for most individuals, creatine supplementation does come with some potential side effects:

Water Retention: Some users experience bloating due to increased water retention in muscle cells.

Gastrointestinal Issues: High doses may lead to stomach upset or diarrhea.

Kidney Concerns: Although rare, prolonged excessive use could strain the kidneys, particularly in individuals with pre-existing conditions.

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Alternatives to Creatine for Myostatin Inhibition

YK-11: A synthetic myostatin inhibitor derived from SARMs, offering more potent results but accompanied by more significant risks.

ACE-031: A peptide that directly inhibits myostatin, though it remains in experimental phases and is not legally approved in many regions.

Natural Alternatives

Follistatin-rich Foods: Eggs and dairy products may have natural myostatin-inhibiting properties.

Resistance Training: Intense and consistent weightlifting alone can naturally lower myostatin levels.

Where to Buy Creatine

Creatine is readily available worldwide. It can be purchased from:

Local Pharmacies and Nutrition Stores: Ideal for trusted and immediate access.

Online Platforms: Websites like Amazon, iHerb, or bodybuilding-specific stores offer a variety of brands and formulations.

Supplement Brands: Well-established brands such as Optimum Nutrition, MyProtein, and Cellucor often carry high-quality creatine.

Legality of Myostatin Inhibitors

Creatine: Creatine is completely legal and widely accepted as a dietary supplement.

YK-11 and ACE-031: These compounds exist in a legal gray area in many countries due to their experimental nature and potential risks. It's essential to research local laws before considering these options.

Best Stores and Suppliers

For reputable products, consider:

Transparent Labs: Known for purity and transparent labeling.

Optimum Nutrition: Offers pharmaceutical-grade creatine monohydrate.

Bulk Supplements: A great choice for bulk buyers seeking affordability and quality.

Our Advice to Bodybuilders

Always consult with a healthcare professional before starting any new supplement, especially if you are already using AAS or other advanced compounds.

Prioritize a balanced diet and consistent exercise routine. Supplements like creatine work best as part of a holistic approach to fitness.

Stay hydrated while using creatine to minimize water retention side effects and support kidney health.

Related Article: Best Syringes for Steroid Injection on Amazon

Overall

While creatine may not be as potent a myostatin inhibitor as advanced compounds like YK-11 or ACE-031, its affordability, safety, and accessibility make it a valuable addition to any bodybuilder's supplement stack. By leveraging its benefits alongside proper training and nutrition, you can maximize muscle growth and overcome plateaus, regardless of your fitness level.

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