Steroids

How Growth Hormone Therapy Enhances Recovery of Patients with Spinal Damage

Published

3 years ago

July 7, 2021

Paul

Researchers have found that combining human growth hormone and physical therapy helps people with severe spinal damage recover faster. The results of the study presented to the European Endocrinology Society show that daily treatment with GH produced significant positive changes in sensory functions of the spinal structure. GH triggers the production of a chemical by the pituitary gland, which helps regenerate new nerves. Although the findings are inconclusive, there is overwhelming evidence that this method could be used to treat people with the condition fully. This article will discuss the efficiency of Growth Hormone Therapy in managing various types of spinal injury.

About Severe Spinal Injury

Spinal injury results from a series of interferences of parts of the nervous system. Denervation, which is the loss of nerve activity in the affected region’, is the most obvious sign that the injury is severe and thus can be described as traumatic. Once the human muscle loses some nerve components, such as endplates and myofibrils, its atrophy changes significantly. Atrophy increases with the denervation level, eventually rendering one virtually immobile.

It is important to note that prolonged spinal injuries are harder to reverse because reinnervation becomes difficult. Even in the case of growth hormone therapy, the procedure's success depends on the length of the period before intervention. That is to say that the sooner a spinal injury is addressed using any medically approved method, the better. The process of axonal generation, which is essential in maintaining a healthy spine, is greatly affected by the affected nerve’s inability to secrete neurotrophic chemicals. The lack of neurotrophic chemicals weakens the burner bands, further complicating recovery from traumatic spinal damage.

Related Article: Human Growth Hormone Role In Bodybuilding

Axonal Regeneration

Axonal regeneration is the only sure way of treating spinal injury. Several therapies have been proposed and experimented with to fix the condition, but the results have not been satisfactory. Most of the methods tested have only managed to accelerate axonal generation have only done so to a certain level. However, scientists and physicians are still conducting more experiments to find a method to help regenerate these important elements to the desired level.

Efficacy of Growth Hormone (HG) in Nerve Regeneration

Among all therapeutic methods tested so far, injection with the growth hormone has been found to have greater success in increasing nerve regeneration for patients with spinal injury. Naturally, the growth hormone is produced by the pituitary gland. However, the body’s ability to produce the hormone may be hindered by factors such as old age, poor diet, or injury. As mentioned earlier, the hormone plays an important role in nerve regeneration. Therefore, its levels can be boosted by administering a synthetic growth hormone.

Additionally, people who have suffered from traumatic spinal injury tend to produce an amount of hormones below normal levels. This phenomenon is quite strange, and scientists continue to try to find the reason behind it. Nevertheless, patients with this problem can be injected with synthetic growth hormone to cater to the deficit. In addition to increasing GH to the required levels, the treatment enhanced nerve regeneration to maintain denervated muscles in patients with compromised nerves.

>> HUMAN GROWTH HORMONE <<

The Research

18 patients with traumatic spinal injury were subjected to a study over six months. The growth hormone level in 13 patients was below normal, a condition known as Growth Hormone Deficiency (GHD). The patients were injected with one dose of artificial growth hormone daily for six months to correct this deficiency. Their recovery process was monitored after the first three months. The patients were also categorized according to age, body mass index (BMI), and waist circumference.

This was necessary because the natural production of the growth hormone varies with the parameters above. As mentioned, the patients also underwent physical therapy sessions to achieve better results. To assess the recovery of the patients, researchers performed simple motor and spinal injury tests. It was established that patients who got a growth hormone injection showed great improvements within three months of treatment. By the sixth month, most patients were fully cured of their spinal injuries.

Lewis rats were put into four groups in similar research to be examined. The first group was a negative control; the other three were subjected to various tests.

Subjected to chronic denervation for eight weeks, followed by nerve transfer (ulnar-to-median).
Underwent denervation for 8 weeks and treated with 0.6g/day of purified GH alongside Ulnawr-to-median nerve transfer.
They did not undergo chronic denervation but were subjected to ulnar-to-median nerve transfer.
Served as the baseline and was used for naïve controls.

Tested Parameters

The four groups were subjected to grip tests weekly for fourteen weeks. Among the parameters being tested in the experiment include:

Median nerve regeneration.
Neuromuscular junction reinnervation.
Flexor digitorum superficialis atrophy.

The test results showed that animals injected with the growth hormone showed greater improvements in median nerve regeneration. Nerve regeneration was measured using the Axon density, diameter, and myelin thickness. Additionally, the experiment revealed that the animals treated with GH showed significant recovery of motor function.

In summary, researchers found out the following from the two tests:

1 Growth hormone enhances axon regeneration.
2 Growth hormone therapy helps maintain chronically deserved muscles.
3 Growth promotes motor reinnervation.
4 Growth hormone enhances functional recovery.

Cumulatively, the effects of the growth hormone help people with severe spinal injuries recover faster. However, the treatment is most helpful when combined with other forms of treatment.

More Research Needed

Although the experiments above have shown the efficacy of the growth hormone in spinal damage treatment, the strategy is still under scientific scrutiny. The results above cannot be relied on fully due to several factors. For instance, the experiment conducted using Lewis rats cannot be used to tell what would happen in the case of humans. The sample size was too small to give conclusive and reliable results. These are only preliminary results but indicate hope for the near future.

Until this study, it was widely believed that damaged axons cannot be repaired in the medical world. If this treatment method is approved, it will be a major game-changer in the medical world. Patients with traumatic spinal injury will no longer feel condemned to the wheelchair forever, thanks to the muscle-maintaining abilities of the growth hormone.

Alternative Therapeutic Treatments

As mentioned earlier, various methods have been tested to determine their efficacy in treating or managing severe spinal injuries. Growth hormone therapy is only one of the several methods still being studied regarding the condition. However, it is important to note that the nature of treatment depends on the severity of the condition. Severe cases of the condition can be managed through surgery and assistive devices that enable affected people to live normal lives without depending on others entirely. Here are some alternative treatments for the condition.

Immobilization

This method stabilizes the spine by bringing it into proper alignment. This is done using various equipment, such as a special bed or a rigid collar.

Surgery –

Spinal surgery is a treatment method to remove bone fragments and other unwanted materials in the injured area. The method also stabilizes the spine and prevents deformities arising from the injury.

Hydrotherapy –

In cases where the patient experiences a lot of pain, water is used to relieve the pain. That can be done by soaking in a hot tub or mineral bath.

Intravenous IV Methylprednisolone Treatment –

This is the most potent non-surgical treatment method for the condition ever found. The treatment is exclusively designed for mild spinal injuries that do not need surgery. However, the chemical has been found to have severe side effects on the patient, such as pneumonia and blood clotting. For this reason, the treatment has been largely stopped.

Rehabilitation –

Although technically not a treatment method, rehabilitation has helped people recovering from spinal injuries face the journey. A team of professionals such as dietitians, physical therapists, and rehabilitation nurses usually care for the patient in the early stages of recovery.

Electrical Stimulation Devices

Sometimes, people with severe spinal injuries cannot move their arms and legs. However, with special electrical stimulation devices, people can easily stand, walk, and grip objects.

Conclusion

Enhances Recovery of Patients with Spinal DamageTraumatic spinal injury happens to many people around the globe annually through accidents and bodily complications. Given the sensitivity of the spinal structure, surgery is never an easy option, hence the need to try safer methods such as growth hormone therapy. As mentioned, treatment with GH has not been fully approved, but it can be used in the meantime. The best thing about this method is that it doesn’t have nasty side effects.

Up Next

New Brutal Force SARMs range – Mad Muscle Gains

Don't Miss

List of Steroid Products Banned by Amazon (Updated 2021)

Paul

Comments

Steroids

Glutathione – The Most Underrated Antioxidant

Published

2 weeks ago

December 10, 2024

Sane

Glutathione, often referred to as the "Master Antioxidant," plays a crucial role in neutralizing free radicals and maintaining cellular health, making it an excellent supplement for bodybuilders across all age groups. Its ability to support liver detoxification, reduce inflammation, and enhance immune function is particularly beneficial for those undergoing intense training or using performance-enhancing drugs (PEDs).

Must Read: Human Chorionic Gonadotropin Hormone

As mentioned, it is a potent antioxidant that the body produces naturally. It plays a key role in detoxification, immune function, and maintaining cellular health.

How Can It Help You?

Glutathione neutralizes harmful free radicals, reducing oxidative stress and shielding cells from damage. This is especially critical for individuals using anabolic steroids or other PEDs, as these substances can increase oxidative stress, burden the liver, and hinder recovery.

Key Benefits of Glutathione Include

Liver Detoxification: Aids the liver in processing toxins, particularly those introduced by PED use.
Reduced Inflammation: Helps mitigate systemic inflammation, enhancing recovery and lowering injury risk.
Enhanced Immunity: Bolsters the immune system, keeping you healthier during intense training cycles.

Additionally, it supports skin health, reduces signs of fatigue, and promotes a general sense of well-being, making it invaluable for athletes focused on both performance and longevity.

How Is It Used?

Glutathione can be taken orally (in liposomal or reduced forms) or via injections for better bioavailability. A typical dose is 500–1000 mg daily if taken orally, or the same amount once a week if injected.

Are There Side Effects?

The hormone is usually well-tolerated. Rare side effects may include mild gastrointestinal discomfort or skin rashes, but these are uncommon. Injected glutathione is considered safe when properly administered.

Alternatives to Glutathione

There are several alternatives to glutathione that can help support your body's antioxidant defenses and overall health:

Vitamin C: This powerful antioxidant helps neutralize free radicals and can also help regenerate glutathione in the body.

Vitamin E: Another potent antioxidant that protects cell membranes from oxidative damage.

N-acetylcysteine (NAC): A precursor to glutathione, NAC can help boost the levels in the body.

Selenium: This trace mineral works synergistically with glutathione to enhance its antioxidant effects.

Milk Thistle: Known for its liver-protective properties, milk thistle can help support glutathione production.

Alpha-lipoic acid (ALA): This antioxidant helps regenerate other antioxidants, including glutathione, and can improve overall antioxidant capacity.

Curcumin: Found in turmeric, curcumin has strong anti-inflammatory and antioxidant properties.

Green Tea Extract: Rich in catechins, green tea extract provides powerful antioxidant benefits.

These alternatives can help maintain your body's antioxidant defenses and support overall health.

Legality of Glutathione Across Different Countries and Territories

The legality of glutathione supplements varies across different countries and territories. Here's a general overview:

United States

Glutathione supplements are widely available and legal in the U.S. They are regulated by the FDA under the Dietary Supplement Health and Education Act (DSHEA) of 19942. The FDA requires that supplements be labeled accurately and that they are safe for consumption.

Canada

In Canada, glutathione supplements are also legal and regulated by Health Canada. They must meet the Natural Health Products Regulations, ensuring safety, efficacy, and quality.

European Union

Glutathione supplements are legal in the EU and are regulated by the European Food Safety Authority (EFSA). They must comply with the EU's Novel Food Regulation if they are marketed as a new food product.

Australia

In Australia, glutathione supplements are legal and regulated by the Therapeutic Goods Administration (TGA). They must be listed on the Australian Register of Therapeutic Goods (ARTG) to be legally sold.

Japan

Its supplements are legal in Japan and are regulated by the Ministry of Health, Labour, and Welfare (MHLW). They must be approved as dietary supplements.

India

In India, glutathione supplements are legal and regulated by the Food Safety and Standards Authority of India (FSSAI). They must comply with the Food Safety and Standards (Food Products Standards and Food Additives) Regulations, 2011.

Other Countries

The legality of glutathione supplements can vary in other countries, and it's essential to check local regulations before purchasing or using them. Some countries may have stricter regulations or require specific approvals for dietary supplements.

Don't Miss: How to Manage Joint Stiffness While on AAS

It's always a good idea to consult with a healthcare professional or regulatory authority in your specific country to ensure compliance with local laws and regulations on the use of Glutathione.

Overall

By mitigating oxidative stress, glutathione helps in faster recovery, reducing injury risks, and promoting overall well-being. Additionally, its role in boosting skin health and combating fatigue adds to its appeal, contributing to both performance and longevity. However, it is essential for users to consult with healthcare professionals before starting any supplement regimen to ensure safety and efficacy, as individual needs and responses can vary. Glutathione's multifaceted benefits make it a valuable tool in the arsenal of bodybuilders aiming to optimize their health and performance.

Bodybuilding

14 Morning Run Safety Tips for Bodybuilding and Fitness

Published

3 weeks ago

November 28, 2024

Sane

Morning Run can be a refreshing way to start the day, but it comes with its own set of challenges and safety concerns. For bodybuilders, who often have rigorous training schedules, it's crucial to take extra precautions to ensure a safe and effective workout. Here are some essential safety tips for bodybuilders who run in the wee hours of the morning:

Must Read: Here Is How to Know Your MRV

1. Plan Your Morning Run Route

Choose a well-lit, familiar route that is safe and free from heavy traffic. Avoid secluded areas and opt for routes with plenty of pedestrian traffic. If possible, run in parks or designated running trails.

2. Wear Reflective Gear

Visibility is key when running in the dark. Wear reflective clothing, shoes, and accessories to ensure that you are seen by drivers and other pedestrians. A headlamp or flashlight can also help you see the path ahead.

3. Inform Someone Before a Morning Run

Always let someone know your running route and expected return time. This way, if something goes wrong, someone will be aware and can alert authorities if necessary.

4. Carry Identification During Morning Run

Wear an ID bracelet or carry identification in your pocket. Include your name, emergency contact information, and any medical conditions or allergies. This information can be crucial in case of an emergency.

5. Stay Alert

Keep your senses sharp and stay aware of your surroundings. Avoid wearing headphones or earbuds, as they can distract you from potential dangers. Instead, listen to the sounds around you and be prepared to react quickly.

6. Run Against Traffic

When running on roads, always run against the direction of traffic. This allows you to see oncoming vehicles and gives you more time to react if needed.

7. Vary Your Routine

Don't run the same route at the same time every day. Varying your route and schedule can help prevent potential attackers from predicting your movements.

8. Carry a Personal Safety Device

Consider carrying a personal safety device, such as a whistle or pepper spray. These items can help you defend yourself if you encounter a threat.

9. Stay Hydrated

Even though it's early in the morning, your body still needs hydration. Drink water before and after your run, and consider carrying a small water bottle with you.

10. Warm Up Properly for Morning Run

Before you start running, take a few minutes to warm up. Stretching and light exercises can help prevent injuries and prepare your muscles for the workout ahead.

11. Dress Appropriately

Wear moisture-wicking clothing to keep cool and dry. Layering is essential, especially in colder months, so you can adjust your clothing as you warm up.

12. Check the Weather

Before heading out, check the weather forecast. Avoid running in extreme conditions, such as heavy rain, thunderstorms, or extreme heat. If conditions are unsafe, consider an indoor workout instead.

13. Trust Your Instincts

If something doesn't feel right, trust your instincts and find a safer location. Your safety is the top priority, and it's better to be cautious than sorry.

14. Post-Run Routine

After your run, take time to cool down and stretch. This helps reduce muscle soreness and improves flexibility. Also, refuel with a healthy breakfast to replenish your energy levels.

Analysing Your Morning Run Route

Running in unsafe areas can put you at risk, especially in the early morning when visibility is low. Here are some routes to avoid:

Secluded or Remote Areas

Avoid running in places that are far from help, such as remote trails or rural roads. These areas can be dangerous if you encounter wildlife or if you get injured and no one is around to help.

Check High-Crime Areas Before Morning Run

Stick to well-lit, populated areas and avoid neighborhoods with high crime rates. If you're unsure about the safety of an area, it's best to find an alternative route.

Avoid Unlit Roads During Morning Run

Running on roads without streetlights can be hazardous, especially if there's no sidewalk. Cars might not see you, and it's harder to see potential hazards on the road.

Busy Highways or Interstates

Avoid running on or near highways where traffic is fast-moving and there's little room for pedestrians. The noise and exhaust can also be harmful.

Construction Zones

Be cautious around areas with ongoing construction. There might be debris, uneven surfaces, and heavy machinery that can pose risks.

Blind Curves and Hills

Routes with sharp turns or steep hills can be dangerous because you can't see oncoming traffic. It's safer to choose routes with good visibility.

Areas with Poor Drainage Aren't Safe for Morning Run

Avoid routes that are prone to flooding or have poor drainage. Wet, slippery surfaces can lead to falls and injuries.

Unfamiliar Trails

Stick to trails you know well. Unfamiliar trails can be tricky to navigate, and you might get lost or encounter unexpected obstacles.

Overall

By following our morning run safety tips, you enjoy the benefits while minimizing the risks. Remember, safety should always come first, and taking these precautions can help ensure a safe and enjoyable workout experience.

Related Article: How to Regulate Your Food Quantity