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HPTA and Endogenous Testosterone Production Side Effects

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         Anabolic steroids of all kinds exhibit shutdown/subdual of endogenous testosterone production. The side effects of testosterone can come to varying degrees. And, the possibility of long-term and total shutdown and suppression of the endocrine systems is almost always high.

           The excessive use of anabolic steroids or testosterone, either in dosing schemes and cycle lengths, can result in side effects.

What Happens to The HPTA?

            The HPTA or Hypothalamic Pituitary Testicular Axis is a specific axis found in the endocrine system. This basically governs the entire production of the testosterone levels of the body. If there is an overdose intake of steroids, the entire axis will become completely inhibited.

          This is specifically in the case of the overdose of exogenous androgens. The worst thing is the long period of time of use of the drug. It might even more result in Leydig Cell desensitization.

Safety and Prevention:

           In the analysis of the cycle of Endogenous Testosterone Production, it will now be essential to follow a suitable and comprehensive post cycle therapy protocol. This mainly involved the collection and the use of compounds of ancillary compounds and testosterone. These compounds include SERMS like Nolvadex.

      In this regard, the use of HCG or testosterone stimulating compounds is essential to further facilitate the easy and fast recovery of HPTA. As per the duration of the PCT programs, it usually can range from four to six weeks. This is specifically right after the anabolic steroids have cleared from the physique.

            Failure to comply with the PCT program may result in permanent damage to HPTA. This is when an individual produces deficient/insufficient testosterone levels. This will follow up by the medical treatment often in the TRT form.

Toxic Side Effects:

       It must be clearly understood that testosterone of different types is not classified as C17-alpha anabolic steroids. This only means that they do not measure any toxicity in the liver. This is assured by the studies which were investigated in the past.

             The studies conducted involved testosterone utilized at high doses like four-hundred milligrams on a daily basis. This is almost equivalent to two-thousand eight-hundred milligrams every week. Administering it orally is better than conventional intramuscular injection.

            This way, it will saturate the organ of the liver with a higher level of Endogenous Testosterone Production. Actually, all oral substances will pass first to the liver and will engage with the liver at a higher rate as compared to the injectable form. It will also be essential for all people to understand that even if hepatotoxicity, also discovered with the use of Testosterone Propionate, it still administer in the form of injection.

          This will, therefore, avoid the process of passing through the liver. This only means to say that hepatotoxicity will never be a major concern when it comes to the side effects of Testosterone.

Cardiovascular Effects:

Cardiovascular System

             It should be clearly noted that cardiovascular negative and strain alterations are all normal effects brought by testosterone. These are all a side effect that can expect from anabolic steroids. The impact may become worse or just better as compared to others. And, it is just normal to observe it with anabolic steroids.

               The negative effects of the cardiovascular system include the reduction of HDL or good cholesterol. The LDL is also further increased. This mainly occurs because the testosterone increases a particular activity called as enzyme hepatic lipase right through the liver.

           Hepatic lipase acts as the enzyme produced in the liver. This is mainly responsible for the breakdown of the HDL cholesterol. The alterations will include an augmented risk increase in cardiovascular disease and arteriosclerosis. These changes will still depend on the duration whereas the extended length may pose an increase in the risk of cardiovascular disease. The negative changes in cholesterol and the risk for cardiovascular disease are the reasons why a short cycle is better.

Must Read: The Do’s And Don’ts Of Low And High-Intensity Cardio

Administration as Another Major Factor That Affects The Changes in Cholesterol:

            Another major factor that can affect the changes in cholesterol level is the route of administration of the anabolic steroid. The testosterone takes place and displays less bearing on the values as compared to anabolic steroids.

           Actually, this is because of the aptitude of the liver to metabolize the testosterone level. This results from the testosterone not to become fully resistant to the metabolism and breakdown.

Why Hepatotoxicity Cases Increase?

          Hepatotoxicity cases increase prior to the involvement of different anabolic steroids that possess a particular trait. This trait includes showing a higher form of resistance to hepatic metabolism as compared to testosterone. This is also the reason why the oral anabolic type of steroids exhibits higher degrees of toxicity.

             Now, the concern that involved anabolic steroid exhibiting a higher form of resistance to the hepatic metabolism will influence the bearing that a particular anabolic steroid can hold on the management of the cholesterol level in the liver.

Clinical Studies Involving Testosterone Production and its Impact on The HDL Cholesterol:

           Testosterone has been clearly examined in some clinical study. It was found out that after a twelve-week period of administering 280 milligrams of Testosterone Enanthate, the profiles for cholesterol changed not for the better but for the worse.

          This was when the administration included the aromatase inhibitor. This resulted in a twenty-five percent drop of the HDL cholesterol.

Prevention of The Side Effects

          It is recommended for people to utilize only a minimal dose of the so-called aromatase inhibitor. This is true during the cycles and for the control of Estrogen. This is a lot better than the elimination of the Estrogen level.

          The practice must follow up to maintain the levels of Estrogen in the normal ranges. This will also help prevent the Estrogen levels to drop below normal levels.

Other Suggested Tips:

Tips

              It also suggests following exquisite care to be able to adjust the nutritional habits. This should also be in favor of positive changes and cholesterol maintenance.

This is true when it comes to the cycles of administering anabolic steroids!. Now, you already have learned about HPTA and Endogenous testosterone production side effects!

Must Read Our Article: Testosterone Enanthate vs. Testosterone Cypionate

Building muscle mass is what I like to talk about. If your aim is to build a solid body, then my posts would be very beneficial to you. I always want to know your opinion, so don't hesitate to drop a line below or contact me.

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Steroids

Tips on How to Store Peptides and HGH

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When peptides are mixed with bacteriostatic water (BAC water), their longevity is highly influenced by how they are stored. Correct storage is crucial, as improper conditions can compromise their quality and reduce their efficacy.

Explore: Hypertrophy Training Program 

Key Storage Guidelines

Room Temperature: Peptides tend to degrade rapidly at room temperature, lasting only a few hours to a day. It's best to use them immediately in this condition.

Refrigeration (2-8°C): When stored in a refrigerator, peptides mixed with BAC water can remain stable for 2-4 weeks. However, some peptides may degrade more quickly than others, so limiting storage to around two weeks is safest.

Freezing (-20°C or lower): For prolonged storage, freezing is the best option, maintaining peptide stability for several months. It is important to avoid multiple cycles of thawing and refreezing, as this can degrade the peptides.

It's important to note that storage guidelines can differ depending on the specific peptide, so always check for the particular recommendations to ensure maximum longevity and effectiveness.

NOTE: Peptides reconstituted with Sterile Water only remain potent for 2-3 days, even under ideal storage conditions. This is because sterile water lacks the antibacterial properties of BAC water, leading to faster bacterial growth and peptide degradation.

Finding Containers to Store Peptides and HGH

You can find containers for storing peptides and HGH at various online retailers and specialty stores. Here are a few options:

Edge Peptides: They offer a range of storage containers suitable for peptides, including glass and high-quality plastic vials.

Peptide Sciences: This site provides information on peptide storage and offers appropriate containers.

Muscle and Brawn: They have guidelines on peptide storage and sell containers designed for this purpose.

Make sure to choose containers that are chemically inert, such as glass or high-quality plastic, to avoid any reactions with the peptides. Additionally, ensure the containers are tightly sealed to prevent contamination and degradation.

What Would Be the Best Peptides and HGH for Beginners?

For beginner bodybuilders and athletes, it's important to start with safe and effective options. Here are some of the best peptides and human growth hormone (HGH) supplements:

Peptides for Muscle Growth

Ipamorelin: Stimulates growth hormone production, aiding muscle growth and fat loss.

CJC-1295: Enhances growth hormone release, promoting muscle growth and improving sleep quality.

Hexarelin: Stimulates growth hormone release, aiding muscle gain and cardiovascular health.

Sermorelin: Increases growth hormone production, beneficial for muscle growth.

GHRP-6: Stimulates growth hormone release, increasing energy levels and aiding muscle growth.

HGH Supplements

CrazyBulk HGH-X2: Boosts HGH production, increases energy levels, and helps build muscle mass.

HyperGH 14x: Promotes muscle growth and improves performance.

GenF20 Plus: Maintains optimal HGH levels, aiding in muscle growth and anti-aging.

PGH-1000: Enhances strength and stamina.

Sytropin: Supports physical fitness, anti-aging, and andropause.

Summary

Storing peptides and human growth hormone (HGH) properly is crucial for maintaining their effectiveness and ensuring safety. Peptides should ideally be stored in a refrigerator at 2-8°C for up to 2-4 weeks when mixed with bacteriostatic water, while freezing them at -20°C or lower extends their stability for several months, but avoid thawing and refreezing. When reconstituting peptides, use bacteriostatic water instead of sterile water to maintain potency for a longer duration (2-4 weeks versus 2-3 days). Use chemically inert containers, like glass or high-quality plastic vials, and ensure they are tightly sealed. Maintain sterility during reconstitution and storage to prevent bacterial contamination.

Use reconstituted peptides as soon as possible to avoid degradation in solution. Popular peptides for muscle growth include Ipamorelin, CJC-1295, Hexarelin, Sermorelin, and GHRP-6, while CrazyBulk HGH-X2 is a common supplement to boost HGH production. Always check the specific storage recommendations for each peptide, as they can vary.

Remember, it's crucial to consult with a healthcare professional before starting any new supplement regimen to ensure it's safe and appropriate for your individual needs.

Must Read: Targeted Training for Individual Muscle Groups 

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Ostarine For Beginners: The Ultimate Guide

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Ostarine, also referred to as MK-2866 or Enobosarm, is among the most extensively used and researched Selective Androgen Receptor Modulators (SARMs). Initially developed to combat muscle-wasting diseases, it has gained immense popularity among athletes and bodybuilders for its muscle-preserving and performance-enhancing benefits.

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How Does It Work?

Ostarine selectively binds to androgen receptors in muscle and bone tissues, promoting protein synthesis and osteogenesis. Unlike anabolic androgenic steroids (AAS), which interact with androgen receptors throughout the body, Ostarine specifically targets certain tissues, reducing the risk of unwanted side effects such as hair loss, high estrogen levels, prostate enlargement, or virilization in women.

Practical Benefits of Ostarine

Muscle Preservation

Ostarine is well-known for its ability to maintain lean muscle mass, especially during calorie deficits. Studies have shown that it prevents muscle wasting while sustaining strength and endurance, making it ideal for cutting cycles (Dalton et al., 2011).

Muscle Growth

Although its muscle-building capacity is milder compared to stronger SARMs or AAS, Ostarine effectively promotes gradual, high-quality muscle gains without excessive water retention.

Improved Recovery

Athletes have reported enhanced recovery times with Ostarine. By reducing muscle breakdown and increasing nitrogen retention, it allows users to train more frequently and intensively.

Bone Health

Ostarine positively impacts bone density. Research indicates its ability to increase bone mineralization, potentially making it a therapeutic agent for osteoporosis (Narayanan et al., 2008). For athletes, this translates to a reduced injury risk and stronger skeletal support during heavy training.

Related Article: Legality of Steroids in Latin America 

Potential Side Effects

Mild Testosterone Suppression

Ostarine can suppress natural testosterone production, particularly at higher doses. Post Cycle Therapy (PCT) is recommended after cycles to restore hormonal balance.

Dyslipidemia

Like most SARMs, Ostarine can affect lipid profiles, potentially lowering HDL (good cholesterol) and increasing LDL (bad cholesterol).

Elevated Liver Enzymes

Some users report mild elevations in liver enzymes during use, though these usually return to normal after discontinuation.

Long-Term Effects

Unknown As a relatively new compound, the long-term effects of Ostarine on health are not fully understood.

How to Use Ostarine Correctly

Dosage and Cycle Recommendations

Ostarine is typically dosed at 10–30 mg per day, depending on the user’s goals and experience level:

For Cutting: 10–20 mg per day to preserve muscle and aid fat loss.

For Bulking: 20–30 mg per day to promote lean muscle gains.

Cycles generally last 6–8 weeks. Longer cycles or higher doses may increase the risk of side effects, including testosterone suppression. With a half-life of approximately 24 hours, Ostarine allows for convenient once-daily dosing.

Post Cycle Therapy (PCT)

We highly recommend PCT following Ostarine cycles, especially for doses exceeding 20 mg per day, to restore natural testosterone levels.

Ostarine Alternatives

For beginner bodybuilders looking for alternatives to Ostarine, here are some popular options:

  1. RAD 140 (Testolone): Known for its excellent muscle-building and fat-burning properties, RAD 140 is a favorite among those looking to gain lean muscle mass.
  2. LGD-4033 (Ligandrol): This SARM is highly effective for increasing strength and muscle mass, making it a great choice for beginners.
  3. Cardarine (GW-501516): Although not technically a SARM, Cardarine is popular for its ability to enhance endurance and fat loss.
  4. YK-11: This SARM is known for its ability to promote muscle growth and strength, similar to anabolic steroids.
  5. S23: Effective for cutting cycles, S23 helps reduce body fat while preserving muscle mass.
  6. Andarine (S4): This SARM is used for both bulking and cutting, offering muscle preservation and fat loss.

These alternatives offer various benefits and can be chosen based on individual goals and preferences. It's always important to research and consult with a healthcare professional before starting any new supplement regimen.

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Overall

Ostarine (MK-2866) is a versatile and beginner-friendly SARM, offering significant benefits for muscle preservation, recovery, and lean growth. Its selective action and mild side-effect profile make it an attractive option for athletes and bodybuilders seeking an edge in performance and aesthetics. However, responsible use, including appropriate dosing, cycle length, and post-cycle therapy, is crucial to minimizing risks and maximizing results.

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Mushroom Chitosan for Skin Care: A Plant-Based Option for Skincare

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Mushroom chitosan is a prominent ingredient in the skincare industry, celebrated for its compatibility with skin, moisturizing properties, and its role in wound healing and skin regeneration. Extracted from the cell walls of specific mushrooms, this eco-friendly, plant-based alternative to traditional chitosan (which is typically derived from shellfish) has recently gained considerable attention. It is swiftly becoming a favored ingredient in products designed to enhance skin texture, reduce inflammation, and improve moisture retention. This article delves into the science behind mushroom chitosan, its skin benefits, and how it compares to other popular ingredients.

Chitosan Overview

Chitosan is a natural polysaccharide traditionally obtained from the exoskeletons of shellfish like shrimp and crabs. However, mushroom chitosan, derived from fungi such as Aspergillus niger and Agaricus bisporus, offers a plant-based, vegan-friendly alternative. It provides similar benefits without the allergens or ethical concerns associated with animal-derived ingredients.

What It Does

Mushroom chitosan exhibits excellent biocompatibility, meaning it works well with human skin without causing irritation or allergic reactions. It is also biodegradable and sustainable, making it a particularly appealing option for eco-conscious consumers.

Mushroom chitosan forms a protective film on the skin’s surface, which helps retain moisture and shields the skin from environmental stressors like pollution and harmful bacteria. This barrier function also enhances the skin’s ability to retain water, making it especially beneficial for individuals with dry or sensitive skin.

Chitosan Magic

Additionally, chitosan has antimicrobial properties that can help prevent and treat skin infections. It promotes wound healing by accelerating the regeneration of skin cells, making it useful for post-inflammatory conditions like acne scars or minor cuts. Here is a summary of the main benefits of using mushroom chitosan:

Enhanced Hydration

Mushroom chitosan’s film-forming ability helps lock in moisture, maintaining the skin’s hydration levels. This is especially beneficial for dry, dehydrated skin or for maintaining a healthy moisture barrier.

Anti-inflammatory

Chitosan has been shown to reduce inflammation, which can soothe irritated or red skin. This makes it effective for people dealing with sensitive skin conditions like eczema or rosacea.

Chitosan Wound Healing and Skin Repair

Studies have shown that chitosan accelerates the skin’s natural healing process, making it a valuable ingredient for wound care and the recovery of damaged skin. It supports the regeneration of healthy skin cells, which can help minimize scarring and promote overall skin health.

Chitosan Antimicrobial Properties

Its ability to inhibit the growth of bacteria and fungi can help reduce breakouts and skin infections, providing a natural solution for acne-prone skin.

Anti-aging Benefits

Mushroom chitosan supports the skin’s elasticity and firmness by maintaining moisture levels and protecting it from oxidative stress, making it an effective anti-aging ingredient. By reducing the appearance of fine lines and improving texture, it contributes to a smoother, youthful complexion.

Related Article: Why A Newbie Must Use Electrolytes

Let's Compare it With Traditional Skin Products

Hyaluronic Acid: Mushroom chitosan and hyaluronic acid are both excellent for retaining moisture in the skin. However, chitosan also offers antimicrobial and wound-healing benefits, making it a multifunctional ingredient.

Collagen: Both ingredients aim to improve skin texture and elasticity. While collagen helps firm and plump the skin, mushroom chitosan focuses on moisture retention, repair, and protective qualities, offering a more comprehensive approach to skincare.

Traditional Chitosan: Mushroom chitosan has an edge over traditional shellfish-derived chitosan as it is plant-based and hypoallergenic. People with shellfish allergies can use it safely, and it’s also suitable for vegans and those seeking sustainable skincare options.

Main Products Containing Mushroom Chitosan

Moisturizers and Serums: As a potent humectant, mushroom chitosan is increasingly used in moisturizing products to boost skin hydration, enhancing the skin’s natural barrier.

Acne Treatments: Thanks to its antimicrobial and anti-inflammatory properties, mushroom chitosan is an excellent ingredient in acne-fighting formulas, reducing bacterial growth while calming inflamed skin.

Wound Healing Creams: Given its regenerative abilities, mushroom chitosan is often included in creams designed to speed up wound healing or reduce scarring, especially for acne-prone skin or post-skin procedures.

Anti-aging Products: Mushroom chitosan’s ability to retain moisture and support the skin’s elasticity makes it a key ingredient in anti-aging serums and creams, helping to reduce the appearance of fine lines and wrinkles.

Overall

Mushroom chitosan is an exciting, versatile ingredient in skincare that addresses multiple concerns, from hydration and inflammation to skin repair and protection. As a vegan-friendly, eco-conscious alternative to traditional chitosan, it offers a sustainable and effective solution for enhancing skin health. With its broad range of benefits and gentle nature, mushroom chitosan is poised to become a staple in modern skincare.

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