Steroids

HPTA and Endogenous Testosterone Production Side Effects

Published

7 years ago

December 25, 2017

Zizou

Anabolic steroids of all kinds exhibit shutdown/subdual of endogenous testosterone production. The side effects of testosterone can come to varying degrees. And, the possibility of long-term and total shutdown and suppression of the endocrine systems is almost always high.

The excessive use of anabolic steroids or testosterone, either in dosing schemes and cycle lengths, can result in side effects.

What Happens to The HPTA?

The HPTA or Hypothalamic Pituitary Testicular Axis is a specific axis found in the endocrine system. This basically governs the entire production of the testosterone levels of the body. If there is an overdose intake of steroids, the entire axis will become completely inhibited.

This is specifically in the case of the overdose of exogenous androgens. The worst thing is the long period of time of use of the drug. It might even more result in Leydig Cell desensitization.

Safety and Prevention:

In the analysis of the cycle of Endogenous Testosterone Production, it will now be essential to follow a suitable and comprehensive post cycle therapy protocol. This mainly involved the collection and the use of compounds of ancillary compounds and testosterone. These compounds include SERMS like Nolvadex.

In this regard, the use of HCG or testosterone stimulating compounds is essential to further facilitate the easy and fast recovery of HPTA. As per the duration of the PCT programs, it usually can range from four to six weeks. This is specifically right after the anabolic steroids have cleared from the physique.

Failure to comply with the PCT program may result in permanent damage to HPTA. This is when an individual produces deficient/insufficient testosterone levels. This will follow up by the medical treatment often in the TRT form.

Toxic Side Effects:

It must be clearly understood that testosterone of different types is not classified as C17-alpha anabolic steroids. This only means that they do not measure any toxicity in the liver. This is assured by the studies which were investigated in the past.

The studies conducted involved testosterone utilized at high doses like four-hundred milligrams on a daily basis. This is almost equivalent to two-thousand eight-hundred milligrams every week. Administering it orally is better than conventional intramuscular injection.

This way, it will saturate the organ of the liver with a higher level of Endogenous Testosterone Production. Actually, all oral substances will pass first to the liver and will engage with the liver at a higher rate as compared to the injectable form. It will also be essential for all people to understand that even if hepatotoxicity, also discovered with the use of Testosterone Propionate, it still administer in the form of injection.

This will, therefore, avoid the process of passing through the liver. This only means to say that hepatotoxicity will never be a major concern when it comes to the side effects of Testosterone.

Cardiovascular Effects:

Cardiovascular System

It should be clearly noted that cardiovascular negative and strain alterations are all normal effects brought by testosterone. These are all a side effect that can expect from anabolic steroids. The impact may become worse or just better as compared to others. And, it is just normal to observe it with anabolic steroids.

The negative effects of the cardiovascular system include the reduction of HDL or good cholesterol. The LDL is also further increased. This mainly occurs because the testosterone increases a particular activity called as enzyme hepatic lipase right through the liver.

Hepatic lipase acts as the enzyme produced in the liver. This is mainly responsible for the breakdown of the HDL cholesterol. The alterations will include an augmented risk increase in cardiovascular disease and arteriosclerosis. These changes will still depend on the duration whereas the extended length may pose an increase in the risk of cardiovascular disease. The negative changes in cholesterol and the risk for cardiovascular disease are the reasons why a short cycle is better.

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Administration as Another Major Factor That Affects The Changes in Cholesterol:

Another major factor that can affect the changes in cholesterol level is the route of administration of the anabolic steroid. The testosterone takes place and displays less bearing on the values as compared to anabolic steroids.

Actually, this is because of the aptitude of the liver to metabolize the testosterone level. This results from the testosterone not to become fully resistant to the metabolism and breakdown.

Why Hepatotoxicity Cases Increase?

Hepatotoxicity cases increase prior to the involvement of different anabolic steroids that possess a particular trait. This trait includes showing a higher form of resistance to hepatic metabolism as compared to testosterone. This is also the reason why the oral anabolic type of steroids exhibits higher degrees of toxicity.

Now, the concern that involved anabolic steroid exhibiting a higher form of resistance to the hepatic metabolism will influence the bearing that a particular anabolic steroid can hold on the management of the cholesterol level in the liver.

Clinical Studies Involving Testosterone Production and its Impact on The HDL Cholesterol:

Testosterone has been clearly examined in some clinical study. It was found out that after a twelve-week period of administering 280 milligrams of Testosterone Enanthate, the profiles for cholesterol changed not for the better but for the worse.

This was when the administration included the aromatase inhibitor. This resulted in a twenty-five percent drop of the HDL cholesterol.

Prevention of The Side Effects

It is recommended for people to utilize only a minimal dose of the so-called aromatase inhibitor. This is true during the cycles and for the control of Estrogen. This is a lot better than the elimination of the Estrogen level.

The practice must follow up to maintain the levels of Estrogen in the normal ranges. This will also help prevent the Estrogen levels to drop below normal levels.

Other Suggested Tips:

Tips

It also suggests following exquisite care to be able to adjust the nutritional habits. This should also be in favor of positive changes and cholesterol maintenance.

This is true when it comes to the cycles of administering anabolic steroids!. Now, you already have learned about HPTA and Endogenous testosterone production side effects!

Must Read Our Article: Testosterone Enanthate vs. Testosterone Cypionate

Steroids

Glutathione – The Most Underrated Antioxidant

Published

2 weeks ago

December 10, 2024

Sane

Glutathione, often referred to as the "Master Antioxidant," plays a crucial role in neutralizing free radicals and maintaining cellular health, making it an excellent supplement for bodybuilders across all age groups. Its ability to support liver detoxification, reduce inflammation, and enhance immune function is particularly beneficial for those undergoing intense training or using performance-enhancing drugs (PEDs).

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As mentioned, it is a potent antioxidant that the body produces naturally. It plays a key role in detoxification, immune function, and maintaining cellular health.

How Can It Help You?

Glutathione neutralizes harmful free radicals, reducing oxidative stress and shielding cells from damage. This is especially critical for individuals using anabolic steroids or other PEDs, as these substances can increase oxidative stress, burden the liver, and hinder recovery.

Key Benefits of Glutathione Include

Liver Detoxification: Aids the liver in processing toxins, particularly those introduced by PED use.
Reduced Inflammation: Helps mitigate systemic inflammation, enhancing recovery and lowering injury risk.
Enhanced Immunity: Bolsters the immune system, keeping you healthier during intense training cycles.

Additionally, it supports skin health, reduces signs of fatigue, and promotes a general sense of well-being, making it invaluable for athletes focused on both performance and longevity.

How Is It Used?

Glutathione can be taken orally (in liposomal or reduced forms) or via injections for better bioavailability. A typical dose is 500–1000 mg daily if taken orally, or the same amount once a week if injected.

Are There Side Effects?

The hormone is usually well-tolerated. Rare side effects may include mild gastrointestinal discomfort or skin rashes, but these are uncommon. Injected glutathione is considered safe when properly administered.

Alternatives to Glutathione

There are several alternatives to glutathione that can help support your body's antioxidant defenses and overall health:

Vitamin C: This powerful antioxidant helps neutralize free radicals and can also help regenerate glutathione in the body.

Vitamin E: Another potent antioxidant that protects cell membranes from oxidative damage.

N-acetylcysteine (NAC): A precursor to glutathione, NAC can help boost the levels in the body.

Selenium: This trace mineral works synergistically with glutathione to enhance its antioxidant effects.

Milk Thistle: Known for its liver-protective properties, milk thistle can help support glutathione production.

Alpha-lipoic acid (ALA): This antioxidant helps regenerate other antioxidants, including glutathione, and can improve overall antioxidant capacity.

Curcumin: Found in turmeric, curcumin has strong anti-inflammatory and antioxidant properties.

Green Tea Extract: Rich in catechins, green tea extract provides powerful antioxidant benefits.

These alternatives can help maintain your body's antioxidant defenses and support overall health.

Legality of Glutathione Across Different Countries and Territories

The legality of glutathione supplements varies across different countries and territories. Here's a general overview:

United States

Glutathione supplements are widely available and legal in the U.S. They are regulated by the FDA under the Dietary Supplement Health and Education Act (DSHEA) of 19942. The FDA requires that supplements be labeled accurately and that they are safe for consumption.

Canada

In Canada, glutathione supplements are also legal and regulated by Health Canada. They must meet the Natural Health Products Regulations, ensuring safety, efficacy, and quality.

European Union

Glutathione supplements are legal in the EU and are regulated by the European Food Safety Authority (EFSA). They must comply with the EU's Novel Food Regulation if they are marketed as a new food product.

Australia

In Australia, glutathione supplements are legal and regulated by the Therapeutic Goods Administration (TGA). They must be listed on the Australian Register of Therapeutic Goods (ARTG) to be legally sold.

Japan

Its supplements are legal in Japan and are regulated by the Ministry of Health, Labour, and Welfare (MHLW). They must be approved as dietary supplements.

India

In India, glutathione supplements are legal and regulated by the Food Safety and Standards Authority of India (FSSAI). They must comply with the Food Safety and Standards (Food Products Standards and Food Additives) Regulations, 2011.

Other Countries

The legality of glutathione supplements can vary in other countries, and it's essential to check local regulations before purchasing or using them. Some countries may have stricter regulations or require specific approvals for dietary supplements.

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It's always a good idea to consult with a healthcare professional or regulatory authority in your specific country to ensure compliance with local laws and regulations on the use of Glutathione.

Overall

By mitigating oxidative stress, glutathione helps in faster recovery, reducing injury risks, and promoting overall well-being. Additionally, its role in boosting skin health and combating fatigue adds to its appeal, contributing to both performance and longevity. However, it is essential for users to consult with healthcare professionals before starting any supplement regimen to ensure safety and efficacy, as individual needs and responses can vary. Glutathione's multifaceted benefits make it a valuable tool in the arsenal of bodybuilders aiming to optimize their health and performance.

Bodybuilding

14 Morning Run Safety Tips for Bodybuilding and Fitness

Published

3 weeks ago

November 28, 2024

Sane

Morning Run can be a refreshing way to start the day, but it comes with its own set of challenges and safety concerns. For bodybuilders, who often have rigorous training schedules, it's crucial to take extra precautions to ensure a safe and effective workout. Here are some essential safety tips for bodybuilders who run in the wee hours of the morning:

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1. Plan Your Morning Run Route

Choose a well-lit, familiar route that is safe and free from heavy traffic. Avoid secluded areas and opt for routes with plenty of pedestrian traffic. If possible, run in parks or designated running trails.

2. Wear Reflective Gear

Visibility is key when running in the dark. Wear reflective clothing, shoes, and accessories to ensure that you are seen by drivers and other pedestrians. A headlamp or flashlight can also help you see the path ahead.

3. Inform Someone Before a Morning Run

Always let someone know your running route and expected return time. This way, if something goes wrong, someone will be aware and can alert authorities if necessary.

4. Carry Identification During Morning Run

Wear an ID bracelet or carry identification in your pocket. Include your name, emergency contact information, and any medical conditions or allergies. This information can be crucial in case of an emergency.

5. Stay Alert

Keep your senses sharp and stay aware of your surroundings. Avoid wearing headphones or earbuds, as they can distract you from potential dangers. Instead, listen to the sounds around you and be prepared to react quickly.

6. Run Against Traffic

When running on roads, always run against the direction of traffic. This allows you to see oncoming vehicles and gives you more time to react if needed.

7. Vary Your Routine

Don't run the same route at the same time every day. Varying your route and schedule can help prevent potential attackers from predicting your movements.

8. Carry a Personal Safety Device

Consider carrying a personal safety device, such as a whistle or pepper spray. These items can help you defend yourself if you encounter a threat.

9. Stay Hydrated

Even though it's early in the morning, your body still needs hydration. Drink water before and after your run, and consider carrying a small water bottle with you.

10. Warm Up Properly for Morning Run

Before you start running, take a few minutes to warm up. Stretching and light exercises can help prevent injuries and prepare your muscles for the workout ahead.

11. Dress Appropriately

Wear moisture-wicking clothing to keep cool and dry. Layering is essential, especially in colder months, so you can adjust your clothing as you warm up.

12. Check the Weather

Before heading out, check the weather forecast. Avoid running in extreme conditions, such as heavy rain, thunderstorms, or extreme heat. If conditions are unsafe, consider an indoor workout instead.

13. Trust Your Instincts

If something doesn't feel right, trust your instincts and find a safer location. Your safety is the top priority, and it's better to be cautious than sorry.

14. Post-Run Routine

After your run, take time to cool down and stretch. This helps reduce muscle soreness and improves flexibility. Also, refuel with a healthy breakfast to replenish your energy levels.

Analysing Your Morning Run Route

Running in unsafe areas can put you at risk, especially in the early morning when visibility is low. Here are some routes to avoid:

Secluded or Remote Areas

Avoid running in places that are far from help, such as remote trails or rural roads. These areas can be dangerous if you encounter wildlife or if you get injured and no one is around to help.

Check High-Crime Areas Before Morning Run

Stick to well-lit, populated areas and avoid neighborhoods with high crime rates. If you're unsure about the safety of an area, it's best to find an alternative route.

Avoid Unlit Roads During Morning Run

Running on roads without streetlights can be hazardous, especially if there's no sidewalk. Cars might not see you, and it's harder to see potential hazards on the road.

Busy Highways or Interstates

Avoid running on or near highways where traffic is fast-moving and there's little room for pedestrians. The noise and exhaust can also be harmful.

Construction Zones

Be cautious around areas with ongoing construction. There might be debris, uneven surfaces, and heavy machinery that can pose risks.

Blind Curves and Hills

Routes with sharp turns or steep hills can be dangerous because you can't see oncoming traffic. It's safer to choose routes with good visibility.

Areas with Poor Drainage Aren't Safe for Morning Run

Avoid routes that are prone to flooding or have poor drainage. Wet, slippery surfaces can lead to falls and injuries.

Unfamiliar Trails

Stick to trails you know well. Unfamiliar trails can be tricky to navigate, and you might get lost or encounter unexpected obstacles.

Overall

By following our morning run safety tips, you enjoy the benefits while minimizing the risks. Remember, safety should always come first, and taking these precautions can help ensure a safe and enjoyable workout experience.

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