Steroids
Liver Functionality: Blood Tests to Monitor It While On Steroids
The liver is the largest internal organ in an adult man, weighing around 1.5 kg. The liver has a central role in our metabolism, i.e.. the process of substance exchange in our body. To enable successful liver functionality, around 1.5 l of blood goes through the liver in a minute, making up around 1/4 of the blood volume delivered from the heart. Two-thirds of this blood volume comes to the liver in the portal vein.
This vein delivers substances absorbed in the digestive tract, processed in the liver, and then either stored in the body or excreted in the bloodstream. Liver cells have numerous metabolic functions that happen thanks to blood delivery.
All liver cells have their role in metabolism: processing proteins, fats, carbs, bilirubin, pancreas acids, vitamins, minerals, and some hormones.
Liver Functionality and Steroids
As mentioned above, the liver is an essential organ that performs many bodily functions. An impaired liver can bring many complications or kill you very fast. It detoxifies the blood and produces bile, which helps break down fats. The liver is vital to our health, and it can be damaged by certain drugs or conditions, such as those that are caused by alcohol abuse or obesity. When this happens, your doctor might prescribe you steroids to help reduce inflammation.
Doctors want to monitor patients' liver functionality while on steroids because it can cause increased levels of cholesterol in the body, which may lead to a heart attack or stroke. This article will discuss how doctors monitor liver functionality while on steroids and how they try to minimize the risk of severe side effects from taking these drugs. Please note that the information contained here is a result of independent research.
Doctors want to monitor patients' liver functionality while on steroids because it can cause increased levels of cholesterol in the body, which may lead to a heart attack or stroke. This article will discuss how doctors monitor liver functionality while on steroids and how they try to minimize the risk of severe side effects from taking these drugs. The liver is an essential organ that performs many functions in the body. It detoxifies the blood and produces bile, which helps break down fats.
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Liver function can be compromised for numerous reasons, one being (ab) using anabolic steroids. To determine if your liver is under stress because of your steroid use, you should do liver blood tests, and here, we shall evaluate some possible blood test options.
GGT – One of The Most Important Blood Test For Evaluating Liver Function:
GGT is an enzyme whose increased values say very specifically about specific liver damage due to medicines (such as steroids) or alcohol abuse. It can also indicate pancreas damage.
According to some research, the GGT value decreases after the meal, so you should give blood for this testing in the morning, before breakfast—consuming the slightest alcohol within 24 hours before testing will elevate the GGT value. GGT is a very sensitive indicator of liver disease. It is increased in any liver disease, so GGT should be done with other analyses to determine the illness in question.
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GGT Increased Values Indicate:
- obstruction of pancreas paths (for example, in the case of pancreas stone)
- any hepatitis type
- Malignant processes in the liver
- infective hepatitis
- fat liver
- alcohol hepatitis
There are some other reasons for increased GGT values, such as:
- Acute or chronic pancreatitis
- alcoholism
- obesity
- diabetes
- hyperthyroidism
- heavy smoking
It must be noted that exercising doesn't have a significant effect on GGT values.
Normal Value GGT:
Average GGT values are different for women; women have significantly lower GGT values in the blood. After 50 years of age, these differences decrease. Children have different reference values. It must be noted that reference values for African people are about two times higher.
The average GGT value removes any reason for concern about liver damage due to steroid use. Increased GGT value indicated a series of problems and is the reason for additional testing, especially in combination with elevated AST/ALT values.
Serum Bilirubin – Another Important Blood Test For Detecting Liver Function:
Bilirubin serum test is another critical test when determining liver function. Elevated bilirubin indicates liver disease because bile doesn't leave the liver as it should. Bile deposits in the liver can happen due to oral anabolic steroids use.
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There are Several Causes For Abnormal Bilirubin Values, Such as:
- gallstone, which obstructs bile excretion
- hepatitis
- tuberculosis, sarcoidosis, lymphoma
- a genetic disease, such as Dubine-Jonson syndrome, Rotor Syndrome
- autoimmune disease, some infections, and other disorders that damage the liver
- Wilson disease
Just as in the case of GGT, bilirubin cannot be elevated due to exercise. It is, of course, best if bilirubin stays within a reference value. However, even when perfectly healthy, quite a few individuals will sometimes exceed the reference limit, as in cases of some infections or alcohol abuse. This means that bilirubin alone is not a complete and definite indicator of liver damage.
ALT Tests:
ALT is an enzyme produced by the liver to metabolize proteins. A VA with a very high level of ALT in the blood can indicate liver damage, which might make it tough to restore liver health. This means that it is recommended not to wait for the ALT value to be high before being concerned about it.
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Conclusion:
If all three tests are normal, i.e., levels of the mentioned enzymes/serum in the blood are within reference values, then your liver is in good health, and there is no reason for worry.
We recommend you read this post on How to protect the liver during the steroid cycle to get more insights on this topic.
Bodybuilding Products
Tips on How to Store Peptides and HGH
When peptides are mixed with bacteriostatic water (BAC water), their longevity is highly influenced by how they are stored. Correct storage is crucial, as improper conditions can compromise their quality and reduce their efficacy.
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Key Storage Guidelines
Room Temperature: Peptides tend to degrade rapidly at room temperature, lasting only a few hours to a day. It's best to use them immediately in this condition.
Refrigeration (2-8°C): When stored in a refrigerator, peptides mixed with BAC water can remain stable for 2-4 weeks. However, some peptides may degrade more quickly than others, so limiting storage to around two weeks is safest.
Freezing (-20°C or lower): For prolonged storage, freezing is the best option, maintaining peptide stability for several months. It is important to avoid multiple cycles of thawing and refreezing, as this can degrade the peptides.
It's important to note that storage guidelines can differ depending on the specific peptide, so always check for the particular recommendations to ensure maximum longevity and effectiveness.
NOTE: Peptides reconstituted with Sterile Water only remain potent for 2-3 days, even under ideal storage conditions. This is because sterile water lacks the antibacterial properties of BAC water, leading to faster bacterial growth and peptide degradation.
Finding Containers to Store Peptides and HGH
You can find containers for storing peptides and HGH at various online retailers and specialty stores. Here are a few options:
Edge Peptides: They offer a range of storage containers suitable for peptides, including glass and high-quality plastic vials.
Peptide Sciences: This site provides information on peptide storage and offers appropriate containers.
Muscle and Brawn: They have guidelines on peptide storage and sell containers designed for this purpose.
Make sure to choose containers that are chemically inert, such as glass or high-quality plastic, to avoid any reactions with the peptides. Additionally, ensure the containers are tightly sealed to prevent contamination and degradation.
What Would Be the Best Peptides and HGH for Beginners?
For beginner bodybuilders and athletes, it's important to start with safe and effective options. Here are some of the best peptides and human growth hormone (HGH) supplements:
Peptides for Muscle Growth
Ipamorelin: Stimulates growth hormone production, aiding muscle growth and fat loss.
CJC-1295: Enhances growth hormone release, promoting muscle growth and improving sleep quality.
Hexarelin: Stimulates growth hormone release, aiding muscle gain and cardiovascular health.
Sermorelin: Increases growth hormone production, beneficial for muscle growth.
GHRP-6: Stimulates growth hormone release, increasing energy levels and aiding muscle growth.
HGH Supplements
CrazyBulk HGH-X2: Boosts HGH production, increases energy levels, and helps build muscle mass.
HyperGH 14x: Promotes muscle growth and improves performance.
GenF20 Plus: Maintains optimal HGH levels, aiding in muscle growth and anti-aging.
PGH-1000: Enhances strength and stamina.
Sytropin: Supports physical fitness, anti-aging, and andropause.
Summary
Storing peptides and human growth hormone (HGH) properly is crucial for maintaining their effectiveness and ensuring safety. Peptides should ideally be stored in a refrigerator at 2-8°C for up to 2-4 weeks when mixed with bacteriostatic water, while freezing them at -20°C or lower extends their stability for several months, but avoid thawing and refreezing. When reconstituting peptides, use bacteriostatic water instead of sterile water to maintain potency for a longer duration (2-4 weeks versus 2-3 days). Use chemically inert containers, like glass or high-quality plastic vials, and ensure they are tightly sealed. Maintain sterility during reconstitution and storage to prevent bacterial contamination.
Use reconstituted peptides as soon as possible to avoid degradation in solution. Popular peptides for muscle growth include Ipamorelin, CJC-1295, Hexarelin, Sermorelin, and GHRP-6, while CrazyBulk HGH-X2 is a common supplement to boost HGH production. Always check the specific storage recommendations for each peptide, as they can vary.
Remember, it's crucial to consult with a healthcare professional before starting any new supplement regimen to ensure it's safe and appropriate for your individual needs.
Steroids
Ostarine For Beginners: The Ultimate Guide
Ostarine, also referred to as MK-2866 or Enobosarm, is among the most extensively used and researched Selective Androgen Receptor Modulators (SARMs). Initially developed to combat muscle-wasting diseases, it has gained immense popularity among athletes and bodybuilders for its muscle-preserving and performance-enhancing benefits.
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How Does It Work?
Ostarine selectively binds to androgen receptors in muscle and bone tissues, promoting protein synthesis and osteogenesis. Unlike anabolic androgenic steroids (AAS), which interact with androgen receptors throughout the body, Ostarine specifically targets certain tissues, reducing the risk of unwanted side effects such as hair loss, high estrogen levels, prostate enlargement, or virilization in women.
Practical Benefits of Ostarine
Muscle Preservation
Ostarine is well-known for its ability to maintain lean muscle mass, especially during calorie deficits. Studies have shown that it prevents muscle wasting while sustaining strength and endurance, making it ideal for cutting cycles (Dalton et al., 2011).
Muscle Growth
Although its muscle-building capacity is milder compared to stronger SARMs or AAS, Ostarine effectively promotes gradual, high-quality muscle gains without excessive water retention.
Improved Recovery
Athletes have reported enhanced recovery times with Ostarine. By reducing muscle breakdown and increasing nitrogen retention, it allows users to train more frequently and intensively.
Bone Health
Ostarine positively impacts bone density. Research indicates its ability to increase bone mineralization, potentially making it a therapeutic agent for osteoporosis (Narayanan et al., 2008). For athletes, this translates to a reduced injury risk and stronger skeletal support during heavy training.
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Potential Side Effects
Mild Testosterone Suppression
Ostarine can suppress natural testosterone production, particularly at higher doses. Post Cycle Therapy (PCT) is recommended after cycles to restore hormonal balance.
Dyslipidemia
Like most SARMs, Ostarine can affect lipid profiles, potentially lowering HDL (good cholesterol) and increasing LDL (bad cholesterol).
Elevated Liver Enzymes
Some users report mild elevations in liver enzymes during use, though these usually return to normal after discontinuation.
Long-Term Effects
Unknown As a relatively new compound, the long-term effects of Ostarine on health are not fully understood.
How to Use Ostarine Correctly
Dosage and Cycle Recommendations
Ostarine is typically dosed at 10–30 mg per day, depending on the user’s goals and experience level:
For Cutting: 10–20 mg per day to preserve muscle and aid fat loss.
For Bulking: 20–30 mg per day to promote lean muscle gains.
Cycles generally last 6–8 weeks. Longer cycles or higher doses may increase the risk of side effects, including testosterone suppression. With a half-life of approximately 24 hours, Ostarine allows for convenient once-daily dosing.
Post Cycle Therapy (PCT)
We highly recommend PCT following Ostarine cycles, especially for doses exceeding 20 mg per day, to restore natural testosterone levels.
Ostarine Alternatives
For beginner bodybuilders looking for alternatives to Ostarine, here are some popular options:
- RAD 140 (Testolone): Known for its excellent muscle-building and fat-burning properties, RAD 140 is a favorite among those looking to gain lean muscle mass.
- LGD-4033 (Ligandrol): This SARM is highly effective for increasing strength and muscle mass, making it a great choice for beginners.
- Cardarine (GW-501516): Although not technically a SARM, Cardarine is popular for its ability to enhance endurance and fat loss.
- YK-11: This SARM is known for its ability to promote muscle growth and strength, similar to anabolic steroids.
- S23: Effective for cutting cycles, S23 helps reduce body fat while preserving muscle mass.
- Andarine (S4): This SARM is used for both bulking and cutting, offering muscle preservation and fat loss.
These alternatives offer various benefits and can be chosen based on individual goals and preferences. It's always important to research and consult with a healthcare professional before starting any new supplement regimen.
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Overall
Ostarine (MK-2866) is a versatile and beginner-friendly SARM, offering significant benefits for muscle preservation, recovery, and lean growth. Its selective action and mild side-effect profile make it an attractive option for athletes and bodybuilders seeking an edge in performance and aesthetics. However, responsible use, including appropriate dosing, cycle length, and post-cycle therapy, is crucial to minimizing risks and maximizing results.
Steroids
Mushroom Chitosan for Skin Care: A Plant-Based Option for Skincare
Mushroom chitosan is a prominent ingredient in the skincare industry, celebrated for its compatibility with skin, moisturizing properties, and its role in wound healing and skin regeneration. Extracted from the cell walls of specific mushrooms, this eco-friendly, plant-based alternative to traditional chitosan (which is typically derived from shellfish) has recently gained considerable attention. It is swiftly becoming a favored ingredient in products designed to enhance skin texture, reduce inflammation, and improve moisture retention. This article delves into the science behind mushroom chitosan, its skin benefits, and how it compares to other popular ingredients.
Chitosan Overview
Chitosan is a natural polysaccharide traditionally obtained from the exoskeletons of shellfish like shrimp and crabs. However, mushroom chitosan, derived from fungi such as Aspergillus niger and Agaricus bisporus, offers a plant-based, vegan-friendly alternative. It provides similar benefits without the allergens or ethical concerns associated with animal-derived ingredients.
What It Does
Mushroom chitosan exhibits excellent biocompatibility, meaning it works well with human skin without causing irritation or allergic reactions. It is also biodegradable and sustainable, making it a particularly appealing option for eco-conscious consumers.
Mushroom chitosan forms a protective film on the skin’s surface, which helps retain moisture and shields the skin from environmental stressors like pollution and harmful bacteria. This barrier function also enhances the skin’s ability to retain water, making it especially beneficial for individuals with dry or sensitive skin.
Chitosan Magic
Additionally, chitosan has antimicrobial properties that can help prevent and treat skin infections. It promotes wound healing by accelerating the regeneration of skin cells, making it useful for post-inflammatory conditions like acne scars or minor cuts. Here is a summary of the main benefits of using mushroom chitosan:
Enhanced Hydration
Mushroom chitosan’s film-forming ability helps lock in moisture, maintaining the skin’s hydration levels. This is especially beneficial for dry, dehydrated skin or for maintaining a healthy moisture barrier.
Anti-inflammatory
Chitosan has been shown to reduce inflammation, which can soothe irritated or red skin. This makes it effective for people dealing with sensitive skin conditions like eczema or rosacea.
Chitosan Wound Healing and Skin Repair
Studies have shown that chitosan accelerates the skin’s natural healing process, making it a valuable ingredient for wound care and the recovery of damaged skin. It supports the regeneration of healthy skin cells, which can help minimize scarring and promote overall skin health.
Chitosan Antimicrobial Properties
Its ability to inhibit the growth of bacteria and fungi can help reduce breakouts and skin infections, providing a natural solution for acne-prone skin.
Anti-aging Benefits
Mushroom chitosan supports the skin’s elasticity and firmness by maintaining moisture levels and protecting it from oxidative stress, making it an effective anti-aging ingredient. By reducing the appearance of fine lines and improving texture, it contributes to a smoother, youthful complexion.
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Let's Compare it With Traditional Skin Products
Hyaluronic Acid: Mushroom chitosan and hyaluronic acid are both excellent for retaining moisture in the skin. However, chitosan also offers antimicrobial and wound-healing benefits, making it a multifunctional ingredient.
Collagen: Both ingredients aim to improve skin texture and elasticity. While collagen helps firm and plump the skin, mushroom chitosan focuses on moisture retention, repair, and protective qualities, offering a more comprehensive approach to skincare.
Traditional Chitosan: Mushroom chitosan has an edge over traditional shellfish-derived chitosan as it is plant-based and hypoallergenic. People with shellfish allergies can use it safely, and it’s also suitable for vegans and those seeking sustainable skincare options.
Main Products Containing Mushroom Chitosan
Moisturizers and Serums: As a potent humectant, mushroom chitosan is increasingly used in moisturizing products to boost skin hydration, enhancing the skin’s natural barrier.
Acne Treatments: Thanks to its antimicrobial and anti-inflammatory properties, mushroom chitosan is an excellent ingredient in acne-fighting formulas, reducing bacterial growth while calming inflamed skin.
Wound Healing Creams: Given its regenerative abilities, mushroom chitosan is often included in creams designed to speed up wound healing or reduce scarring, especially for acne-prone skin or post-skin procedures.
Anti-aging Products: Mushroom chitosan’s ability to retain moisture and support the skin’s elasticity makes it a key ingredient in anti-aging serums and creams, helping to reduce the appearance of fine lines and wrinkles.
Overall
Mushroom chitosan is an exciting, versatile ingredient in skincare that addresses multiple concerns, from hydration and inflammation to skin repair and protection. As a vegan-friendly, eco-conscious alternative to traditional chitosan, it offers a sustainable and effective solution for enhancing skin health. With its broad range of benefits and gentle nature, mushroom chitosan is poised to become a staple in modern skincare.
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