Steroids

Steroids 101, Cycles, Dosage, and full Idiots Guide

Published

5 years ago

December 25, 2019

Paul

Steroids are the hormones the human body naturally produces. They enable the optimal functioning of your cells, tissue, and organs. They also refer to synthetic drugs made by man, that have cortisol-like effects.

These Steroids can also be grouped in two:

Corticosteroids
Anabolic-androgenic Steroids (anabolics)

Corticosteroids which are usually called ‘Steroids’ are very different from anabolics which are steroid compounds used by athletes to enhance their performances. These steroids are used to treat include allergies, asthma, dermatitis, hives, Addison's disease, Crohn’s diseases, leukemia, prostate cancer, etc. Corticosteroids can be absorbed into the body in the form of eye drops, ear drops, creams, inhalers.

Synthetic drugs used in different forms:

Oral Steroids:

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These steroids are used in the treatment of several health conditions, but especially for the controlling of inflammations.

Topical Steroids:

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These are medications in the form of creams, lotions, ointments, solutions, serums, gels, sprays, foam, oils, shampoos and other substances made for using them on the skin or scalp. It also includes eye drops used for the treatment of eye inflammation.

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Steroid Nasal Sprays:

These medications usually used to treat tightness in the nasal cavity, for example, allergies like asthma and hay fever.

Steroid Inhalers:

These medications are also for the treatment of lung conditions. They absorbe into the body by breathing their content into the lungs.

Steroid Injections:

These usually treat and relieve joint issues caused by inflammation and stiffness such as arthritis.

Corticosteroids prescribed for the following reasons:

Addison’s disease: This is a condition where your adrenal glands do not secrete sufficient cortisol for the body’s use.
Inflammation: Inflammation is a condition that occurs when the body’s immune system is fighting off bacteria and foreign substances to protect the body against infection. Inflammation can have adverse effects on the body’s organs. Corticosteroids can control inflammations.
Organ Transplants: In an event when organ transplant its done, corticosteroids taken to lower the function of the immune system so the new organ is not rejected by the body.
Autoimmune diseases: Corticosteroids are used to reduce the effects of the malfunctioning of the body’s immune system.

Classification of synthetic Corticosteroids:

Corticosteroids can be classified into the following:

Glucocorticoids: These steroids help to reduce the effects of inflammation and reduce the functioning of the immune system. Their functions also include the depletion of these major food groups; fats, proteins, and carbohydrates.
Mineralocorticoids: These steroids control salt and water equilibrium in the body. Some glucocorticoids also have salt retaining capacity.

There are many examples of synthetic corticosteroids which perform different functions in the body and can be further grouped under Glucocorticoids and Mineralocorticoids. A few examples of synthetic corticosteroids in forms of pills and injections are:

Methylprednisolone, Dexamethasone, Triamcinolone, Prednisolone, Betamethasone, Prednisone, Cortisone, Medrol, Orasone, Celestone, Kenalog, Decadron, Kenacort, Hydeltrasol, Delta-corf, Aristocort, Cinalone, Fludrocortisone, etc.

Different examples of Corticosteroids are administered in the case of the following conditions:

Arthritis, Colitis, Asthma, Bronchitis, Skin Rashes, Allergies, Anemia, Addison’s disease, Eczema, Dandruff, Psoriasis, Lichen Planus, Discoid Lupus Erythematosus, Inflammatory Bowel Disease, Hives, Hay Fever, Multiple Sclerosis.

Side effects of using Corticosteroids:

Synthetic steroids should use according to prescription. The regular use or the use of large quantities of synthetic Corticosteroids over a prolonged period can result in side effects. These side effects may vary depending on the type or form of corticosteroids but they can prevent sticking to prescriptions when taking drugs. These side effects may vary in different people and may not happen to everyone who uses it for a long time.

Side effects that could occur from the excessive and prolonged inhaling of corticosteroids are Cough, Sore throat, Difficulty with Speech, Nose bleeding, Oral Thrush, etc. Side effects that could occur from excessive and prolonged injecting of corticosteroids are skin loss, insomnia, and high levels of blood sugar.

This side effects could occur from excessive and prolonged oral intake of corticosteroids are acne, water retention, increased appetite, stomach irritation, insomnia, depression, thinning of skin layer, high blood pressure, delayed clotting, peptic ulceration, Cushing syndrome, vulnerability to infections, extreme fatigue, weakness of the muscle, cataracts, facial hair growth, glaucoma, easy bruising of the skin, moon face, salt retention, irregular menstrual cycles, obesity, euphoria, osteoporosis, shrinking of adrenal glands, adrenal necrosis of hip joints, nausea, shock caused by adrenal crisis, etc.

Who should use Corticosteroids?

If you have conditions like diabetes, heart, liver, thyroid, kidney diseases, stomach problems, blood pressure or mental health issues, be careful while using steroids as it can make these conditions worse. Also, if you have infections such as HIV, AIDS, herpes simplex, tuberculosis, fungal infection, you should also apply caution while using this medication.

If you have also just undergone a surgical procedure or have a serious injury, you have to also consider this while using these medications. If you wear contact lenses, avoid using steroids in the form of eye drops while wearing them. Also, if you have been diagnosed with systemic sclerosis, you have to be careful about the dosage of prednisolone you take as this can worsen the situation.

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Older people may be at risk of osteoporosis after a long duration of using corticosteroids and children may be at risk of stunted growth, chickenpox or measles infections. If you have infected skin, broken skin or skin conditions like acne and open sores, avoid the use of topical steroids for treatment. Steroids should only be used by pregnant and nursing mothers in necessary situations. Research shows that the prolonged use and abuse of these substances can cause defects in the unborn child.

Topical Steroids

Therefore, the use of topical steroids with high potency should not be practiced by nursing and breastfeeding mothers. There is no proof if the content can make contact with the breast milk mother apply all caution during usage, of topical steroids, even of low potency. Do not apply topical steroids to a nursing mother’s breasts and if she must use these medications, she should also be careful to wash off the cream from her breasts before breastfeeding her child. This safety measure is very important to prevent the child from being harmed.

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If you need to combine the use of other drugs while using these steroids, ensure you inform your doctor to avoid these drugs interacting with steroids and causing adverse effects. Some drugs that may have a high propensity of interacting with steroids include anticoagulants, drugs for the treatment of epilepsy and diabetes and Xofigo.

While using steroids, it is advised that you avoid vaccinations such as yellow fever as they have different risks possibilities. The consumption of alcohol and steroid tablets can cause serious stomach problems. You would need to reduce alcohol intake while using steroids. The use of tobacco can also cause complications for you while using steroids.

Certain food substances should not be consumed while using steroids as doing so may further lead to more complications and health issues. For instance, don't consume grapefruit juice while using steroids.

Anabolic Steroids (Anabolics)

Anabolic steroids, also called anabolic-androgen steroids (AAS) are androgens that include testosterone. They are also synthetic derivations of testosterone that bring about the development of masculine characteristics. These characteristics include the deepening of the voice and facial hair. The anabolic part of the term refers to muscle building while the androgen part refers to male features. They usually referred to as Arnolds, gym candy, pumpers, roids and stackers, gear, juice on the street.

Anabolics lead to several changes in different parts of the body like the muscles, liver, kidney, blood, bones, hair follicles, immune system, reproductive system, and central nervous system. Anabolics are used for different purposes including medical purposes.

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The different usage methods followed by those misusing these medications include:

Cycling: This involves the use of several doses for cycles of 6-12 weeks and then a stoppage period of about a month. Then, you begin the cycle again.
Stacking: This involves the combination of more than one steroid or the use of supplements or the use of both oral and injectable forms of steroids.
Pyramiding: This involves the gradual increase of dosage of steroids used until you arrive at the zenith then reduce again to zero intakes.
Plateauing: This is switching the use of steroids to minimize the risks of creating tolerance.

Regardless of the method being used, there is no proof these methods prevent or reduce the risks associated with abusing these drugs. Anabolics are popularly divided into 32 types and are used for various purposes. They are used for medical purposes but other purposes include:

Building and developing muscles.
Endurance and strength.
Depleting of fat stored in the body.
Recovery purposes.
Enhancement of performance especially in sports.
Quick body metabolism.

How can we take steroids?

Orally through the mouth
Through the use of injections
Through the implanting of pellets under the skin layer
Applied as a cream, lotion or gel.

Anabolics used orally do make an effective method of absorption. While applying in cream or gel form makes a highly inefficient method of absorption.

Anabolic-androgen steroids move around the body using the blood as a medium. They move to the muscle tissues where they get bound to an androgen receptor. Through this means, they make contact with the DNA composition of the cell, to kick start the process of cell growth.

Dosages

Anabolics are taken according to prescribed dosages. Different types of anabolics have different dosages attached to them. It advises you seek the proper dosage from your doctor for each type of anabolics you intend using. These dosages grouped into:

Clinical Dosage ranges of oral and injectable androgens and anabolic steroid.
Androgen replacement therapy formulations and dosages used in men.
Androgen replacement therapy formulations and dosages used in women.
Androgen/anabolic steroid dosages for breast cancer.

Uses of Anabolics:

Medical Uses of Anabolics

The medical uses of anabolics categorized according to the different effects and situations that require their usage:

Anabolic:

Used for the stimulation of bone marrow and therapy purposes in cases of leukemia, anemia and kidney failure.
Also used to correct cases of growth conditions by stimulating growth, especially in children.
Effective in helping patients, especially with cancer to stimulate their appetite.Used to reduce the loss of bones in elderly men.
They are effective with weight gain and reduce the effect of weight loss, especially after serious surgery.
Used to aid with recovery from sunburns.
They are effective in the treatment of alcoholic hepatitis.
Also used in the treatment of delayed puberty.
AAS is effective in the treatment of erectile dysfunction.
AAS, when given in low dosages, can correct menopausal symptoms.
These steroids increase libido, hot flashes, sexual energy.
They are also effective in the treatment of breast cancer.

Androgenic:

They are effective in improving libido for men and as a treatment for men with low production of testosterone.
They are effective in dealing with delayed puberty in young boys.
Also, they used for therapy for transgender men and intersex fellows by creating male characteristics.

Other uses include the treatment of breast cancer in women, although its use, in this case, has been greatly reduced. They are also used as therapy for transgender women to cause the development and increase of libido and strength. Women also use them for going through menopause as a method of reducing hot flashes.

Use of Anabolics for enhancement purposes:

Anabolics are also for the enhancement of performances by individuals and athletes alike. AAS are used by individuals who are displeased with their performance rate in life; for example at work. They also sued by those wanting to enhance their looks to look more appealing in the eyes of observers.

Athletes and individuals also use AAS in other forms of sporting activities, as a way to maintain a competitive advantage over their opponents or to aid in the recovery from injuries. Using steroids for other purposes besides medical is illegal in most countries. This is especially for use among sportsmen and women in different games or sporting activities. These activities include shotput, weightlifting, wrestling, boxing, running, bodybuilding, cycling, racing, baseball, football, cricket, etc. Athletes usually may go through doping tests to ascertain if they used these substances as a way of ensuring fair competition. However, some athletes use specially designed steroids to pass these tests.

Risk of Anabolic Steroid Addiction

Anabolic steroid users who self-medicate are often at risk to be addict to the use of these substances. Despite the many odds of abusing these substances which include health issues, financial and social consequences, these users still go the extra mile to ensure they have access to these substances. Some get obsessed about the effects of these substances on their overall look. Also, the performance and cannot afford to function without their performance by these drugs.

Misuse of these drugs; the excessive or regular use and the use of these drugs over a long duration come with adverse effects. One such effect is the consequences of anabolic steroid abuse on the brain. Though they do not have the same kind of effects as other abused substances, like causing the ‘high’ moments, the abuse of anabolic steroids can also have the following effects on the brain:

Excessive jealousy and moments of paranoia.
Intense irritability and unexplained rage.
Moments of near madness behavior.
Believing and living by false ideas.

Other side effects of abusing these anabolic steroids include:

Fluid retention.
Having difficulty when passing out urine.
Increased red cell count.
Low sperm count.
Significant loss of growth of hair.
Acne
Fluid retention.
Changes in libido.
Stretch marks
Scalp baldness.
Reversible infertility.
Affective Disorders.
Aggression.
Glucose intolerance.
Muscle sprains.
Jaundice.
Hepatitis.
Acute renal failure.
Insulin resistance.
Immune dysfunction.

Abuse of Anabolic Androgen Steroids also bring about the following:

Reduction in size of testicles in men
Reduces sperm count in men.
Causes men to develop mammary glands.
Baldness or loss of scalp hair in men.
Increase in facial hair in women.
Spontaneous penis erection in men.
Reduction in breast size.
Baldness or loss of scalp hair in women.
Irregularity in the menstrual cycle.
Higher sex drive in women
Increase in size of the clitoris.
Broad voice.
Ovarian cysts in women.
Stunted growth in adolescents.
Stunted height in teens.
Premature sexual development in teens.

Other risks to body organs created by the abuse of anabolic steroids include:

Cardiac arrest.
Tumors.
Tendon rupturing.
Bone loss.
Cardiovascular issues.
Kidney failure.
Liver problems.
High blood pressure
Stroke.
Increased size of the heart.
Blood clotting.
Coronary heart disease.
Increase in bad cholesterol.
Inhibition to the production of sperm

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There are also effects that associate with withdrawal from the use of thee drugs. They include:

Extreme tiredness.
Restlessness.
Inability to sleep.
Mood Swings and Depression.
Reduced sex drives.
Abnormal cravings.

Individuals who abuse these drugs buy from unlicensed suppliers and at a hue or absorbing bad products. They also contracting certain diseases just by sharing a needle with another steroid addict.

Treatment for Anabolic-Androgen Addiction and Abuse

The addiction to these substances usually begins gradually, as an effort to sustain a particular look or level of performance. The first effort to make while attempting to break free from the addiction to these substances is to discontinue the use of these substances. There has to be an effort to stop the purchase and abuse of these substances immediately. Making attempts to outgrow this addiction while still using it even in bits, can prove abortive. The earlier you put an end to it, the faster your body adjusts to the changes that occur as a result of your decision.

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The next step would be to seek the professional help of therapists. This would include behavioral therapists who can assist with all the psychological symptoms of withdrawal or side effects of the abuse of these substances.

Medications can also prove to be very helpful in situations like this. Doctors ca prescribe drugs to help manage the symptoms of withdrawal. These drugs can also use to correct behavioral and psychological effects such as depression. They can also use to cause a recovery of the normal functioning of the hormone system.

For extreme cases of chronic addiction, getting help in an addiction treatment facility should be strongly considered.

Duration of Treatment:

The duration of treatment and recovery is not the same for everyone. However, it usually influence the period through which these medications have been used; the longer the period of use would mean a longer period for recovery. The duration of recovery and the time it would take for the body to return to normal functionality would depend on the treatment used as well.

Conclusion

In conclusion, though the synthetic forms of steroids produced to enhance the general quality of life, there has to be an effort to prevent abuse of the substance. Do not take steroids without a prescription or regularly as a way of boosting one’s total look or to alleviate pain. Do not use them in very large quantities and over a long duration. The safest way to use these substances to ensure there is no adverse effect on the body organs is to use them when necessary. According to the prescription given by your doctor and over the specific period, they ought to have been used.

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Steroids

Why Post-Cycle Therapy (PCT) Fails After a Nandrolone Cycle

Published

1 week ago

February 12, 2025

Sane

Nandrolone, or Deca Durabolin, is an injectable anabolic steroid often used by bodybuilders during the off-season to increase muscle mass. It was initially described in 1960 and was introduced to the market by the pharmaceutical company Organon in 1962. In this article, we are going to discuss its cycle and how PCT might fail after the cycle.

The long-lasting metabolites of nandrolone make post-cycle therapy (PCT) ineffective due to their prolonged suppression of the hypothalamic-pituitary-gonadal (HPG) axis.

Even after discontinuing the drug, its metabolites, like 19-norandrosterone and 19-noretiocholanolone, can stay in the body for over a year.

This persistence prevents the natural recovery of testosterone production, as the pituitary gland still senses the presence of external androgens.

Since PCT drugs such as Clomid and Nolvadex work by stimulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to restore testosterone levels, their effectiveness is limited as long as nandrolone metabolites remain in the body.

Consequently, users often experience prolonged low testosterone levels, making complete hormonal recovery nearly impossible after a nandrolone cycle.

Therefore, the only viable approach after a nandrolone cycle is to continue using testosterone for at least 12 months before attempting a PCT.

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How a Beginner and Pro Responds to PCT After a Nandrolone Cycle

The response to post-cycle therapy (PCT) can vary significantly between beginner and professional bodybuilders due to several factors:

Beginner Bodybuilders

Faster Recovery: Beginners, especially those in their late teens or early 20s, often recover more quickly from steroid cycles. Their bodies haven't been exposed to anabolic steroids for long, so their natural hormone production can bounce back faster.

Less Aggressive PCT: Beginners typically require a less aggressive PCT protocol. They might only need basic medications like Clomid or Nolvadex to help restore natural testosterone levels.

Fewer Compounds: Beginners are usually advised to avoid using multiple recovery agents, as these can sometimes cause more side effects than the low testosterone itself.

Professional Bodybuilders

Slower Recovery: Professional bodybuilders, who have been using steroids for longer periods and in higher doses, often experience a slower recovery. Their bodies have adapted to the presence of exogenous hormones, making it harder to restore natural hormone production1.

More Aggressive PCT: Professionals may need a more comprehensive and aggressive PCT protocol, including medications like HCG, Aromatase Inhibitors (AIs), and other advanced recovery agents.

Experience with Side Effects: Professional bodybuilders are more likely to have experienced side effects from both the steroid cycles and the PCT medications, so they might need a more tailored approach to manage these effects.

Beginners generally have an easier time recovering from steroid cycles and require a simpler PCT regimen, while professionals need a more intensive and customized approach due to their longer exposure to anabolic steroids and higher tolerance to recovery medications.

Popular Nandrolone(Deca Durabolin) Cycles

Deca Durabolin-Only Cycle

Deca Durabolin is mainly utilized for bulking, but since it only promotes moderate lean muscle gain (by bodybuilding standards), it's often combined with other, stronger anabolic-androgenic steroids (AAS).

Typically, combining steroids can amplify side effects, like raising cholesterol and liver enzyme levels. However, in the case of Deca Durabolin, stacking it with other steroids can actually help reduce negative effects on sexual health by increasing androgen levels.

As a result, experienced bodybuilding patients rarely use Deca Durabolin alone. Instead, they combine it with other steroids to maintain high androgen levels and reduce the risk of erectile dysfunction during their cycle.

Deca Durabolin and Dianabol Cycle

Experienced steroid users, who have previously cycled testosterone and developed some tolerance to anabolic steroids, typically undertake this steroid cycle.

We've observed that this combination can result in a weight gain of 30-40 pounds and a strength increase of 50-70 pounds in compound lifts. Some of the weight gained will be due to water retention, which is expected as Dianabol activates the aromatase enzyme.

This cycle carries the risk of gynecomastia because of the elevated levels of progesterone (from Deca Durabolin) and estrogen (from Dianabol). To counteract the conversion of testosterone to estrogen, an anti-aromatase inhibitor (AI) can be used. However, we have found that AIs can raise blood pressure, so we do not generally recommend them.

Deca Durabolin and Anadrol Cycle

The mentioned cycle is typically favored by advanced steroid users due to Anadrol's severe impact on the body, particularly regarding cardiovascular and liver strain.

Anadrol, at doses of 50–100 mg per day, can independently cause hypertension. Additionally, it affects hepatic lipase, an enzyme that, when activated, can significantly lower HDL cholesterol levels.

The risk of gynecomastia is heightened with this cycle, as Deca Durabolin increases progesterone levels and Anadrol elevates estrogen levels.

Aromatase inhibitors (AIs) are ineffective in managing Anadrol's estrogenic effects, as Anadrol does not convert to estrogen but rather directly stimulates estrogen receptors.

Selective estrogen receptor modulators (SERMs) like Clomid or Nolvadex can inhibit estrogen activity at the receptor level, thus preventing gynecomastia caused by Anadrol.

However, these SERMs can also increase progesterone levels, potentially exacerbating nandrolone-induced gynecomastia when used in this stack.

Some steroid users may attempt to prevent gynecomastia during this cycle by using an aromatase inhibitor (AI) to reduce progesterone (not estrogen) levels. However, this approach can worsen cardiovascular strain due to decreased estrogen levels. Additionally, gynecomastia induced by Anadrol remains a concern even when using an AI.

Deca Durabolin and Testosterone Cycle

This bulking cycle is not the most cardiotoxic stack, but changes in cholesterol levels are anticipated, leading to mild to moderate increases in blood pressure.

Deca Durabolin and testosterone are among the most cardiovascular-friendly steroids. Testosterone pairs well with Deca Durabolin because of its androgenic properties, which help mitigate Deca Durabolin's sexual side effects. Unlike Anadrol, testosterone achieves this without severely affecting other health aspects, such as the liver.

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We find this cycle more suitable for individuals concerned about gynecomastia, as an aromatase inhibitor (AI) can be used to lower both estrogen and progesterone levels synergistically.

Two AI medications commonly used by our clients are:

Anastrozole

Letrozole

Endogenous testosterone levels will drop significantly, necessitating a PCT. Some users may experience hair thinning, recession, or loss on the scalp due to testosterone increasing DHT (dihydrotestosterone) levels. In our experience, this cycle is less favorable for hair compared to the Deca Durabolin/Dianabol stack.

Recommended Nandrolone Alternatives

Here are 10 alternatives to Nandrolone for post-cycle therapy (PCT) for bodybuilders, along with detailed explanations:

Tamoxifen Citrate (Nolvadex)

A Selective Estrogen Receptor Modulator (SERM) that helps restore natural testosterone production by blocking estrogen receptors in the brain. It's commonly used in PCT to prevent gynecomastia and other estrogen-related side effects1.

Clomiphene Citrate (Clomid)

Another SERM that works similarly to Tamoxifen by blocking estrogen receptors and stimulating the body's natural production of testosterone. It's often used in PCT to help restore hormonal balance.

Aromatase Inhibitors (AIs)

Medications like Anastrozole (Arimidex) and Letrozole (Femara) that inhibit the enzyme aromatase, which converts testosterone to estrogen. AIs are used in PCT to reduce estrogen levels and support natural testosterone production.

Human Chorionic Gonadotropin (hCG)

A hormone that mimics luteinizing hormone (LH) and stimulates the testes to produce testosterone. It's used in PCT to maintain testicular size and function during and after a steroid cycle.

Testosterone Replacement Therapy (TRT)

Involves the use of exogenous testosterone to restore natural testosterone levels after a cycle. TRT can help maintain muscle mass and overall well-being during PCT.

Dianabol (Metandienone)

An anabolic steroid that can be used in PCT to help maintain muscle mass and strength while the body recovers from a steroid cycle.

Trenbolone Enanthate

A powerful anabolic steroid that can be used in PCT to help maintain muscle mass and strength. It's often used in combination with other PCT medications.

Human Growth Hormone (HGH)

A hormone that stimulates growth, cell reproduction, and cell regeneration. HGH can be used in PCT to help maintain muscle mass and overall well-being.

Insulin-like Growth Factor 1 (IGF-1)

A hormone that promotes cell growth and division. IGF-1 can be used in PCT to help maintain muscle mass and support recovery.

Natural Supplements

There are various natural supplements available that can support PCT, such as Tribulus Terrestris, Fenugreek, and Zinc. These supplements can help boost testosterone levels and support overall recovery.

It's important to consult with your physician and fitness coach before starting any post-cycle therapy to ensure it's safe and appropriate for your individual needs.

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Mitigating a Failed PCT After a Nandrolone Cycle

There are several remedies and strategies to address a failed post-cycle therapy (PCT) after a Nandrolone cycle. Here are some options:

Extended PCT: Sometimes, extending the duration of your PCT can help. This might involve continuing with medications like Tamoxifen or Clomiphene for a longer period.

Combination Therapy: Using a combination of medications such as Tamoxifen, Clomiphene, and Aromatase Inhibitors (AIs) can be more effective than using a single medication.

Human Chorionic Gonadotropin (hCG): Adding hCG to your PCT regimen can help stimulate natural testosterone production and maintain testicular size and function.

Testosterone Replacement Therapy (TRT): If natural testosterone levels are not recovering, TRT can be considered to restore hormonal balance.

Natural Supplements: Supplements like Tribulus Terrestris, Fenugreek, and Zinc can support natural testosterone production and overall recovery.

Lifestyle Changes: Improving diet, reducing stress, and ensuring adequate sleep can support hormonal balance and recovery.

Consulting a Healthcare Professional: It's crucial to consult with a healthcare professional to assess your specific situation and adjust your PCT regimen accordingly.

Monitoring Hormone Levels: Regularly monitoring hormone levels can help track progress and make necessary adjustments to the PCT plan.

Avoid Further Steroid Use: Avoiding additional steroid cycles until natural hormone levels are fully restored is essential.

Patience and Consistency: Recovery can take time, so being patient and consistent with your PCT regimen is key.

Overall

A failed post-cycle therapy (PCT) after a Nandrolone cycle occurs when the body fails to restore its natural hormonal balance. This results in persistent symptoms such as fatigue, decreased libido, mood swings, and issues like gynecomastia, water retention, and erectile dysfunction. Additionally, there's a noticeable loss of muscle mass and strength, and high levels of estrogen and progesterone can lead to further complications like increased body fat and emotional instability.

Prolonged suppression of natural testosterone poses long-term health risks, including cardiovascular issues and bone density loss. Addressing a failed PCT requires consulting with a healthcare professional to develop a tailored recovery plan, which may involve extended PCT, hormone replacement therapy, or lifestyle changes.

Related Article: First Injectable Steroid Cycle

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Counteracting Anabolic Resistance with Adaptogens in Aging Men

Published

4 weeks ago

January 28, 2025

Sane

As people age, maintaining muscle mass and strength becomes increasingly challenging due to a natural condition called anabolic resistance. This phenomenon, where muscles become less responsive to exercise and protein intake, can start as early as age 40. However, adaptogens—herbs that help the body adapt to stress—are emerging as promising allies in combating this resistance and promoting muscle health.

Understanding Anabolic Resistance Symptoms

Aging athletes may experience several symptoms of anabolic resistance, including:

Decreased Muscle Protein Synthesis

Muscles become less responsive to protein, affecting growth and recovery.

Increased Cortisol Levels

Chronic stress raises cortisol levels, which can lead to muscle breakdown.

Hormonal Decline

Natural decreases in testosterone and growth hormone reduce muscle-building capacity.

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Top Adaptogens for Muscle Health

Some of the most commonly used adaptogens include Ashwagandha, Rhodiola Rosea, and Panax Ginseng. Their key benefits are:

Ashwagandha

- Supports testosterone levels.
- Reduces cortisol, improving recovery and muscle maintenance.
- Enhances endurance for sustained workouts.

Rhodiola Rosea

- Lowers fatigue and increases stamina.
- Reduces stress, supporting muscle retention.

Panax Ginseng

- Boosts energy levels for longer, more effective workouts.
- Supports immune function, aiding in recovery.

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How Adaptogens Support Muscle Tissue and Overall Health

Adaptogens help counteract anabolic resistance by:

Regulating Hormones

Ashwagandha may optimize testosterone and growth hormone levels, essential for muscle maintenance.

Lowering Cortisol Levels

High cortisol can exacerbate anabolic resistance. Adaptogens like Rhodiola and Ashwagandha help reduce cortisol, fostering a more anabolic environment.

Enhancing Energy and Endurance

Rhodiola and Ginseng boost energy levels, helping athletes maintain workout intensity, crucial for combating anabolic resistance.

Boosting Recovery and Reducing Fatigue

Ashwagandha aids muscle recovery, and Rhodiola reduces fatigue, both vital for consistent training intensity.

Tips for Integrating Adaptogens into Your Routine

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To incorporate adaptogens into your daily life, consider these tips:

Start Small

Begin with a lower dose to gauge your body's response.

Cycle Use

Use adaptogens for 6-8 weeks, then take a short break to reset and maintain their effectiveness.

Choose Quality Supplements

Opt for third-party tested and certified supplements to ensure potency and purity.

More Options to Counteract Anabolic Resistance in Older Men

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When it comes to counteracting anabolic resistance in older men, it's important to consider both safety and efficacy. Here are some options that might be beneficial:

Selective Androgen Receptor Modulators (SARMs): These compounds are designed to mimic the effects of anabolic steroids without the severe side effects. They can help increase muscle mass and strength.

Testosterone Boosters: Supplements like Adaptophen contain natural ingredients such as Tongkat Ali, Siberian Rhodiola Rosea, and Elk Antler Velvet, which are promoted to boost testosterone levels, improve muscle growth, and aid recovery.

Human Growth Hormone (HGH): HGH supplements can help increase muscle mass and strength, but they should be used under medical supervision due to potential side effects.

Ecdysterone: This compound is found in certain plants and has been shown to have anabolic effects similar to anabolic steroids but with fewer side effects.

Turkesterone: Another natural compound that has shown promise in increasing muscle mass and strength without the harsh side effects of anabolic steroids.

It's crucial to consult with a healthcare professional before starting any new supplement regimen, especially if you have underlying health conditions or are taking other medications. They can help you determine the best course of action based on your individual needs and health status.

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Recommended Exercises to Restore Muscle In Older Men

Restoring muscle loss in older men can be effectively achieved through a combination of resistance training and functional exercises. Here are some of the most effective exercises:

Dumbbell Squats: These help build lower body strength and muscle mass. Stand with feet shoulder-width apart, holding dumbbells at your sides, and squat down while keeping your chest up.

Incline Dumbbell Bench Press: This exercise targets the upper chest and shoulders. Lie on an incline bench, holding dumbbells, and press them upwards until your arms are fully extended.

Chest-Supported Dumbbell Rows: Great for strengthening the back muscles. Adjust the bench to an incline, chest-supported, and pull the dumbbells towards your torso while keeping your back straight.

Planks: Excellent for core strength and stability. Hold a forearm plank position, keeping your body in a straight line from head to heels.

Bird Dogs: This exercise improves core strength and balance. Start in a tabletop position, extend one arm and the opposite leg, and hold for a few seconds before switching sides.

Bodyweight Exercises: Exercises like push-ups, lunges, and step-ups are also beneficial for maintaining muscle mass and overall strength.

Incorporating these exercises into a regular workout routine can help combat muscle loss and improve overall fitness. Remember to start slowly and gradually increase the intensity to avoid injury.

Conclusion

While adaptogens are not a substitute for a balanced diet or structured training, they offer a natural way for aging athletes to manage anabolic resistance. By supporting hormonal balance, reducing stress, enhancing energy, and aiding in recovery and fatigue, adaptogens like Ashwagandha, Rhodiola Rosea, and Panax Ginseng can help athletes, especially those over 40, stay strong and healthy as they age.

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Steroids

Tips on How to Store Peptides and HGH

Published

1 month ago

January 9, 2025

Sane

When peptides are mixed with bacteriostatic water (BAC water), their longevity is highly influenced by how they are stored. Correct storage is crucial, as improper conditions can compromise their quality and reduce their efficacy.

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Key Storage Guidelines

Room Temperature: Peptides tend to degrade rapidly at room temperature, lasting only a few hours to a day. It's best to use them immediately in this condition.

Refrigeration (2-8°C): When stored in a refrigerator, peptides mixed with BAC water can remain stable for 2-4 weeks. However, some peptides may degrade more quickly than others, so limiting storage to around two weeks is safest.

Freezing (-20°C or lower): For prolonged storage, freezing is the best option, maintaining peptide stability for several months. It is important to avoid multiple cycles of thawing and refreezing, as this can degrade the peptides.

It's important to note that storage guidelines can differ depending on the specific peptide, so always check for the particular recommendations to ensure maximum longevity and effectiveness.

NOTE: Peptides reconstituted with Sterile Water only remain potent for 2-3 days, even under ideal storage conditions. This is because sterile water lacks the antibacterial properties of BAC water, leading to faster bacterial growth and peptide degradation.

Finding Containers to Store Peptides and HGH

You can find containers for storing peptides and HGH at various online retailers and specialty stores. Here are a few options:

Edge Peptides: They offer a range of storage containers suitable for peptides, including glass and high-quality plastic vials.

Peptide Sciences: This site provides information on peptide storage and offers appropriate containers.

Muscle and Brawn: They have guidelines on peptide storage and sell containers designed for this purpose.

Make sure to choose containers that are chemically inert, such as glass or high-quality plastic, to avoid any reactions with the peptides. Additionally, ensure the containers are tightly sealed to prevent contamination and degradation.

What Would Be the Best Peptides and HGH for Beginners?

For beginner bodybuilders and athletes, it's important to start with safe and effective options. Here are some of the best peptides and human growth hormone (HGH) supplements:

Peptides for Muscle Growth

Ipamorelin: Stimulates growth hormone production, aiding muscle growth and fat loss.

CJC-1295: Enhances growth hormone release, promoting muscle growth and improving sleep quality.

Hexarelin: Stimulates growth hormone release, aiding muscle gain and cardiovascular health.

Sermorelin: Increases growth hormone production, beneficial for muscle growth.

GHRP-6: Stimulates growth hormone release, increasing energy levels and aiding muscle growth.

HGH Supplements

CrazyBulk HGH-X2: Boosts HGH production, increases energy levels, and helps build muscle mass.

HyperGH 14x: Promotes muscle growth and improves performance.

GenF20 Plus: Maintains optimal HGH levels, aiding in muscle growth and anti-aging.

PGH-1000: Enhances strength and stamina.

Sytropin: Supports physical fitness, anti-aging, and andropause.

Summary

Storing peptides and human growth hormone (HGH) properly is crucial for maintaining their effectiveness and ensuring safety. Peptides should ideally be stored in a refrigerator at 2-8°C for up to 2-4 weeks when mixed with bacteriostatic water, while freezing them at -20°C or lower extends their stability for several months, but avoid thawing and refreezing. When reconstituting peptides, use bacteriostatic water instead of sterile water to maintain potency for a longer duration (2-4 weeks versus 2-3 days). Use chemically inert containers, like glass or high-quality plastic vials, and ensure they are tightly sealed. Maintain sterility during reconstitution and storage to prevent bacterial contamination.

Use reconstituted peptides as soon as possible to avoid degradation in solution. Popular peptides for muscle growth include Ipamorelin, CJC-1295, Hexarelin, Sermorelin, and GHRP-6, while CrazyBulk HGH-X2 is a common supplement to boost HGH production. Always check the specific storage recommendations for each peptide, as they can vary.

Remember, it's crucial to consult with a healthcare professional before starting any new supplement regimen to ensure it's safe and appropriate for your individual needs.

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