Steroids

Thyroid Hormones For Fat Loss In Women

Published

10 years ago

January 28, 2015

Zizou

Thyroid hormones play a significant role in regulating metabolism and can impact body weight and fat loss. However, using thyroid hormones for fat loss in women or anyone else should only be done under the guidance and supervision of a qualified healthcare professional. Self-administering thyroid hormones can have serious health risks and is not a safe or effective way to lose weight.

Here are some important things you need to know about thyroid hormones:

Thyroid Function

The thyroid gland produces two primary hormones, thyroxine (T4) and triiodothyronine (T3), which are key in regulating metabolism. When there is an imbalance in these hormones, it can affect metabolism and potentially lead to weight gain or difficulty losing weight.

Hypothyroidism

Hypothyroidism is when the thyroid gland produces insufficient thyroid hormones. Symptoms can include weight gain, fatigue, and difficulty losing weight. In such cases, healthcare professionals may prescribe synthetic thyroid hormone replacement therapy, such as levothyroxine, to restore normal thyroid function.

Hyperthyroidism

Hyperthyroidism is when the thyroid gland produces an excess of thyroid hormones. This can lead to weight loss, increased metabolism, and other symptoms. Identifying and treating the underlying cause of hyperthyroidism is essential, as simply using thyroid hormones for weight loss can be dangerous.

Risks of Self-Medication

Self-administering thyroid hormones can be dangerous in treating hypothyroidism or for weight loss purposes. It can lead to serious health complications, including heart problems, bone loss, and other adverse effects.

Individual Variation

People's responses to thyroid hormones can vary widely. What works for one person may not work for another, and improper use can lead to health problems.

Healthy Lifestyle

A balanced diet and regular exercise is the most effective and safe way to lose fat and maintain a healthy weight. A healthcare professional can guide a personalized weight loss plan.

Consult a Healthcare Professional

If you suspect you have a thyroid disorder or are struggling with weight issues, it's essential to consult a healthcare professional for proper evaluation and guidance. They can diagnose any thyroid conditions and recommend appropriate treatments if necessary.

Real Life Scenario

A 40-year-old woman claimed to be active in the sport. She started to join swimming competitions when she was a kid and eats healthily on organic foods. She, however, admitted her big appetite for eating after training is helpless. Also, she never really counts calories, but fortunately, with the sports she does, she never has an issue with weight or body fat. As years pass, she can’t keep off the fat and took T4 wrongly. The overdose of T4 has led her to bulk. The heart rate began to increase, but the fat loss program was effective, although it caused more trouble.

Then she tried T3, but this time, with a proper 100 mcg/day dosage. However, another problem occurred as the heart rate affected her training, and the fat loss program was no longer effective. She supported her training with fat loss supplements, including thyroid hormone.

But another question comes to mind: is it effective? And what about the difference between T3 and T4?

This woman’s case is a genetically gifted one. She can stay slim while having a big appetite. Not everyone can maintain a lean body while eating a lot and rely only on training. At the age of 40, the case is different. Our body will experience a certain degradation, and getting back a lean body might not be easy, like when you are 20. Hence, calories are the things to avoid if you want to lose fat.

Fat Loss Supplements:

Fat loss supplements may be effective for some people. It reduces your appetite released by the chemical substance in the supplement. In return, it raises the metabolic rate and the process. This significant loss of appetite causes an individual to eat less – and lose fat. The supplement products generally work like this.

Must Read: Supplements for Gaining Mass and Those For Muscle Definition

The T3 Effect

When you take T3, your food must ‘work’ to match the calorie-burning rate. This way, you don’t lose fat.

The T4 Effect

T4 is rather extreme or stronger than T3. And you will have fat loss.

Thyroid Hormones: Don’t Overdose it

It is important to note that thyroid hormones must not be abused. Once you overdose, it is hard to recover. The powder is not recommended; however, if an individual needs to take it, it must be in a very small dose and prescribed by a nutritionist if possible because there must be an exact 100% certainty.

Some women have been reportedly gaining weight, which is a noticeable sign that they have overdosed on the thyroid. Even when they have struggled, they can’t figure out why. The wrong dosage causes thyroid impairment, slowing down your rate.

The Recommended Intake of Thyroid Hormone:

A healthcare professional should determine the dosage of thyroid hormones (T3 and T4) for women looking to lose weight or manage their thyroid condition based on individual needs and medical history. Self-administering thyroid hormones for weight loss without proper medical guidance can be dangerous and unnecessary.

Here are some tips on T3 and T4 and their roles in thyroid function and metabolism:

T4 (Thyroxine): T4 is the primary hormone produced by the thyroid gland. It is relatively inactive but is converted into the more active T3 in various body tissues, including the liver. T4 medications are commonly prescribed for hypothyroidism (underactive thyroid).
T3 (Triiodothyronine): T3 is the more biologically active form of thyroid hormone. It plays a crucial role in regulating metabolism and energy production. In some cases, healthcare providers may prescribe T3 medication (liothyronine) in addition to or instead of T4 for certain thyroid conditions.

When it comes to weight management:

Hypothyroidism: If a woman has been diagnosed with hypothyroidism, she may be prescribed T4 (levothyroxine) medication to restore thyroid hormone levels to normal. The goal of treatment is to alleviate symptoms of hypothyroidism, such as fatigue, weight gain, and cold intolerance, rather than using thyroid medication solely for weight loss.
Weight Loss and Thyroid Medication: Using thyroid hormones, whether T3 or T4, as a weight loss tool, is not recommended and can be dangerous. Inappropriate use of thyroid hormones can lead to hyperthyroidism, which can have serious health consequences, including heart problems and bone loss.

It's important to emphasize that thyroid medication should only be prescribed and adjusted by a healthcare provider based on thyroid function tests, medical history, and symptoms. If you suspect you have a thyroid issue or are experiencing difficulty with weight management, consult a healthcare professional for a proper evaluation and treatment plan. They will consider the appropriate T3 and/or T4 dosage based on your specific needs and monitor your progress to ensure safety and effectiveness.

What Are the Appropriate Dosages?

Here are some general guidelines for dosages, but it's essential to follow your healthcare provider's recommendations, as they will determine the appropriate dosage based on your weight needs:

Levothyroxine (T4):
- For hypothyroidism: The typical starting dose for adults is 25-50 micrograms (mcg) per day, with adjustments made based on blood tests and symptoms. The goal is to reach a stable TSH (Thyroid-Stimulating Hormone) level within the normal range.
- Maintenance dose: The average maintenance dose for most adults with hypothyroidism ranges from 75 to 150 mcg per day, although it can be higher or lower depending on the individual.
Liothyronine (T3):
- T3 is not typically used as a standalone treatment for hypothyroidism but is sometimes prescribed with T4 medications when necessary.
- When used in combination therapy with T4, a common ratio is 1 part T3 to 4 parts T4 (e.g., 5 mcg T3 with 20 mcg T4). The specific dosages should be determined by your healthcare provider based on your condition and response to treatment.
Hyperthyroidism:

In cases of hyperthyroidism, the goal is typically to reduce thyroid hormone levels. Your healthcare provider would determine the dosages of antithyroid medications (such as Methimazole or Propylthiouracil) and adjust based on your thyroid hormone levels.

Caution!

It's crucial to take thyroid medications exactly as prescribed and to follow up with your healthcare provider for regular blood tests and monitoring. Thyroid hormone replacement therapy is highly individualized, and the correct dosage can vary widely from person to person.

Additionally, certain factors can affect the absorption of thyroid medications, such as other medications, dietary habits, and gastrointestinal conditions. Therefore, you must inform your healthcare provider about any other medications or supplements you are taking and any changes in your health status.

Never adjust your thyroid medication dosage without consulting your healthcare provider, as improper dosing can lead to adverse effects or inadequate treatment of thyroid disorders. Always seek guidance from a qualified medical professional. In summary:

The best dosage is less than 50 mcg/day for T3. You need to divide it into 3 doses.
The best dosage of T4 is less than 200 mcg/day.

T4 vs T3:

T4 has a longer effect when used than T3. Hence, it is preferable to take T4. However, for some individuals, T3 is proven to be more effective. People find that T3 is more convenient in terms of conversion.

Thyroid Affects Most Women:

There are many reasons why women have thyroid issues, and here are some of the factors

Pregnancy
PMS
And per menopause

The calorie intake must be well monitored. The dose of thyroid hormone needs to be a certain number allowed because it will affect the metabolic rate.

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Overall

In summary, thyroid hormones are essential for regulating metabolism. They can influence body weight, but using them for fat loss should only be done under medical supervision when diagnosed with a thyroid disorder. Self-medication or misuse of thyroid hormones for weight loss is unsafe and not recommended. A holistic approach to weight management, including diet and exercise, should be the first defense in achieving and maintaining a healthy weight.

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Steroids

Creatine vs Myostatin: An Expert’s Analysis

Published

1 week ago

March 20, 2025

Sane

Myostatin, a protein encoded by the MSTN gene, acts as a regulator of muscle growth. High levels of myostatin limit the body's ability to build muscle, effectively putting a cap on potential hypertrophy. Inhibiting myostatin has become a focal point for bodybuilders looking to break through plateaus and achieve significant muscle gains. The question is: can creatine, a popular and widely available supplement, help in this regard?

Medical History of Myostatin and Creatine

Myostatin and creatine, while popular now in the bodybuilding world, have their roots in entirely different contexts:

Myostatin: Natural Muscle Growth Regulator

Myostatin is a protein originally identified for its role in regulating skeletal muscle mass. In nature, it serves an evolutionary purpose: by limiting muscle growth, it conserves energy, ensuring that animals (and humans) don’t expend unnecessary resources maintaining excessive muscle tissue. This was especially important in the wild, where energy efficiency could mean the difference between survival and extinction.

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In the medical field, research into myostatin has focused on its role in muscle-wasting diseases. Scientists are exploring ways to inhibit myostatin to treat conditions like muscular dystrophy, where excessive muscle loss impairs quality of life. This therapeutic potential is where the idea of myostatin inhibition first began—long before bodybuilders latched onto the concept.

Creatine: Energy and Medical Applications

Creatine was originally studied for its role in energy metabolism. It’s a naturally occurring compound stored in muscle cells and plays a critical part in replenishing ATP (adenosine triphosphate), the body’s primary energy currency during short, high-intensity activities.

Before becoming a bodybuilding staple, creatine gained recognition in medical and sports science for its ability to improve athletic performance and assist with recovery. Furthermore, in medicine, creatine was investigated for neurological conditions such as Parkinson’s disease, Huntington’s disease, and muscular dystrophy, given its potential to improve muscle function and brain energy metabolism.

In the sports world, it was initially adopted by sprinters and weightlifters in the 1970s and 1980s for its energy-enhancing benefits.

Both myostatin and creatine have found new life in bodybuilding circles, demonstrating how discoveries in natural physiology and medical science can lead to transformative applications in fitness.

Benefits of Creatine as a Myostatin Inhibitor

Muscle Growth Potential: Research suggests that creatine, when paired with intense resistance training, may inhibit myostatin to a degree, fostering an environment for enhanced muscle growth.

Improved Exercise Performance: Creatine is well-known for its ability to increase ATP production, translating to better performance during high-intensity activities.

Versatility Across Fitness Levels

Whether you're a beginner or an advanced athlete, creatine offers benefits that complement various stages of muscle-building.

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Affordability and Accessibility

Compared to specialized myostatin inhibitors like YK-11 and ACE-031, creatine is significantly more affordable and accessible.

Side Effects of Creatine

While generally safe for most individuals, creatine supplementation does come with some potential side effects:

Water Retention: Some users experience bloating due to increased water retention in muscle cells.

Gastrointestinal Issues: High doses may lead to stomach upset or diarrhea.

Kidney Concerns: Although rare, prolonged excessive use could strain the kidneys, particularly in individuals with pre-existing conditions.

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Alternatives to Creatine for Myostatin Inhibition

YK-11: A synthetic myostatin inhibitor derived from SARMs, offering more potent results but accompanied by more significant risks.

ACE-031: A peptide that directly inhibits myostatin, though it remains in experimental phases and is not legally approved in many regions.

Natural Alternatives

Follistatin-rich Foods: Eggs and dairy products may have natural myostatin-inhibiting properties.

Resistance Training: Intense and consistent weightlifting alone can naturally lower myostatin levels.

Where to Buy Creatine

Creatine is readily available worldwide. It can be purchased from:

Local Pharmacies and Nutrition Stores: Ideal for trusted and immediate access.

Online Platforms: Websites like Amazon, iHerb, or bodybuilding-specific stores offer a variety of brands and formulations.

Supplement Brands: Well-established brands such as Optimum Nutrition, MyProtein, and Cellucor often carry high-quality creatine.

Legality of Myostatin Inhibitors

Creatine: Creatine is completely legal and widely accepted as a dietary supplement.

YK-11 and ACE-031: These compounds exist in a legal gray area in many countries due to their experimental nature and potential risks. It's essential to research local laws before considering these options.

Best Stores and Suppliers

For reputable products, consider:

Transparent Labs: Known for purity and transparent labeling.

Optimum Nutrition: Offers pharmaceutical-grade creatine monohydrate.

Bulk Supplements: A great choice for bulk buyers seeking affordability and quality.

Our Advice to Bodybuilders

Always consult with a healthcare professional before starting any new supplement, especially if you are already using AAS or other advanced compounds.

Prioritize a balanced diet and consistent exercise routine. Supplements like creatine work best as part of a holistic approach to fitness.

Stay hydrated while using creatine to minimize water retention side effects and support kidney health.

Related Article: Best Syringes for Steroid Injection on Amazon

Overall

While creatine may not be as potent a myostatin inhibitor as advanced compounds like YK-11 or ACE-031, its affordability, safety, and accessibility make it a valuable addition to any bodybuilder's supplement stack. By leveraging its benefits alongside proper training and nutrition, you can maximize muscle growth and overcome plateaus, regardless of your fitness level.

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Raloxifene (Evista) 101: A Non-Surgical Solution for Gyno

Published

3 weeks ago

March 11, 2025

Sane

Raloxifene, a selective estrogen receptor modulator (SERM), is one of the most valuable yet less common options available today. Originally developed to prevent and treat breast cancer similar to Tamoxifen, it has gained popularity among bodybuilders seeking to prevent or eliminate gyno.

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Unlike Tamoxifen, Raloxifene is potent enough to reduce long-standing gynecomastia and is frequently used to reverse pubertal gynecomastia. While it can also boost testosterone levels, it is one of the weaker SERMs in this regard.

How it Works

Raloxifene functions by blocking estrogen receptors in the breasts, which helps prevent or treat both gynecomastia and breast cancer. Additionally, it blocks estrogen receptors in the hypothalamus, stimulating testosterone production.

Beyond these primary benefits, Raloxifene can enhance bone mass, combat osteoporosis, and lower cholesterol levels.

Potential Side Effects

While Raloxifene is considered a generally safe and effective medication, like all drugs, it comes with its own set of potential side effects. One of the most notable is the reduction in Insulin-like Growth Factor 1 (IGF-1) levels. IGF-1 plays a key role in muscle growth and repair, so decreased levels could potentially impact athletic performance or recovery.

However, compared to other medications in its class, Raloxifene has a relatively low risk of causing severe liver toxicity. Users are less likely to experience harmful effects such as blood clots, mood swings, or sexual dysfunction, making it a preferable choice for many.

While rare, some users might experience less serious side effects such as hot flashes, leg cramps, or flu-like symptoms. It's essential to consult with a healthcare professional to monitor any adverse reactions and ensure the medication is being used safely.

So, despite its efficacy, Raloxifene is not without side effects, but they are typically manageable and less severe compared to other SERMs.

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For gyno reversal, the typical protocol involves taking 60mg daily for 1-2 weeks, followed by 30mg daily for up to 3 months or until the condition resolves.

Typical Protocol

For gynecomastia reversal, the typical protocol involves taking 60mg of Raloxifene per day for 1-2 weeks, followed by a reduced dose of 30mg per day for up to 3 months or until the gynecomastia is resolved. In post-cycle therapy (PCT), bodybuilders generally take 60mg per day for 4-6 weeks, and then lower the dose to 30mg per day during the last week. Raloxifene is highly effective for managing gynecomastia and supporting post-cycle recovery, making it a valuable addition to a well-optimized bodybuilding regimen.

Overall

Raloxifene (Evista) is a versatile SERM used to treat breast cancer and is popular among bodybuilders for managing gynecomastia (gyno). Unlike Tamoxifen, it effectively shrinks long-standing gyno and reverses pubertal gyno. It blocks estrogen receptors in the breast and hypothalamus, thus preventing gyno and promoting Testosterone secretion. Additionally, it improves bone mass, combats osteoporosis, and lowers cholesterol levels. For gyno, take 60mg/day for 1-2 weeks, then 30mg/day for up to 3 months. For post-cycle therapy (PCT), take 60mg/day for 4-6 weeks, then reduce to 30mg/day during the final week. This safe and effective medication has minimal side effects.

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Bodybuilding

Mastering Bodybuilding in 2025: Top Fitness Tips for Success

Published

4 weeks ago

March 1, 2025

Sane

Bodybuilding is more than just a sport; it's a lifestyle that requires dedication, discipline, and a thorough understanding of fitness principles. As the world of fitness continues to evolve, bodybuilders must stay updated with the latest trends, techniques, and scientific advancements to achieve their goals. In 2025, several innovative approaches are redefining bodybuilding. Here are essential fitness tips for bodybuilders to excel this year.

Embrace Technology-Driven Workouts

In 2025, technology plays a significant role in bodybuilding. Wearable devices, fitness apps, and virtual reality (VR) training are now integral components of an effective workout regimen.

Wearable Devices

Modern wearables track everything from heart rate and sleep patterns to muscle activation and caloric expenditure. Utilize these devices to monitor your progress and make data-driven adjustments to your training and nutrition plans.

Fitness Apps

Leverage fitness apps for customized workout plans, progress tracking, and virtual coaching. Many apps now incorporate artificial intelligence to provide personalized feedback and recommendations.

Virtual Reality Training

VR technology offers immersive workout experiences, allowing bodybuilders to simulate different training environments and scenarios. This can enhance motivation and add variety to your routine.

Focus on Functional Strength

While hypertrophy (muscle growth) remains a primary goal, functional strength is gaining importance. Functional strength training improves overall performance, reduces the risk of injury, and enhances daily activities.

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Compound Movements

Incorporate compound exercises like squats, deadlifts, and bench presses. These movements engage multiple muscle groups and joints, promoting balanced strength development.

Core Stability

Prioritize exercises that strengthen the core, such as planks, Russian twists, and leg raises. A strong core supports better lifting mechanics and reduces the risk of lower back injuries.

Optimize Nutrition for Muscle Growth and Recovery

Nutrition is the cornerstone of successful bodybuilding. In 2025, the focus is on personalized nutrition plans tailored to individual needs and goals.

Protein Intake

Ensure adequate protein intake to support muscle repair and growth. Aim for 1.6 to 2.2 grams of protein per kilogram of body weight per day, depending on your training intensity and goals.

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Nutrient Timing

Pay attention to nutrient timing to maximize muscle recovery and growth. Consume protein and carbohydrates within 30 minutes post-workout to replenish glycogen stores and kickstart muscle repair.

Supplements

Utilize supplements wisely. Creatine, branched-chain amino acids (BCAAs), and omega-3 fatty acids are popular choices for enhancing performance and recovery.

Prioritize Mental Health and Mindfulness

Mental health is increasingly recognized as a critical component of overall fitness. Incorporating mindfulness practices can improve focus, reduce stress, and enhance performance.

Meditation

Incorporate meditation into your daily routine to reduce stress and improve mental clarity. Mindfulness meditation can enhance your mind-muscle connection during workouts.

Visualization

Use visualization techniques to mentally rehearse your workouts. Visualizing successful lifts and achieving your goals can boost confidence and motivation.

Rest and Recovery

Prioritize rest and recovery to prevent burnout and overtraining. Ensure you get 7-9 hours of sleep per night and incorporate rest days into your training schedule.

Leverage Advanced Training Techniques

Advanced training techniques can help break through plateaus and stimulate muscle growth. In 2025, several methods are gaining popularity among bodybuilders.

Blood Flow Restriction (BFR) Training: BFR involves restricting blood flow to the muscles during low-intensity exercises. This technique can enhance muscle growth and strength without the need for heavy weights.

Eccentric Training: Focus on the eccentric (lowering) phase of exercises. Eccentric training can stimulate greater muscle damage and growth compared to traditional concentric movements.

Periodization: Implement periodization into your training plan. Varying the intensity, volume, and type of exercises can prevent plateaus and ensure continuous progress.

Incorporate Recovery and Mobility Work

Recovery and mobility are essential for preventing injuries and maintaining optimal performance. In 2025, bodybuilders are paying more attention to these aspects of training.

Foam Rolling and Myofascial Release: Use foam rollers and massage balls to release muscle tightness and improve flexibility. Regular myofascial release can reduce soreness and enhance recovery.

Stretching: Incorporate dynamic stretching before workouts and static stretching after workouts. Stretching improves range of motion and prevents muscle imbalances.

Cryotherapy and Hydrotherapy: Explore recovery techniques like cryotherapy (cold therapy) and hydrotherapy (water therapy) to reduce inflammation and accelerate muscle recovery.

Engage in Continuous Learning and Community Building

The fitness industry is constantly evolving, and staying informed is crucial for success. Engage in continuous learning and connect with the bodybuilding community for support and motivation.

Educational Resources: Read books, watch videos, and attend seminars to stay updated on the latest research and trends in bodybuilding.

Community Engagement: Join online forums, social media groups, and local bodybuilding clubs. Sharing experiences and knowledge with fellow bodybuilders can provide valuable insights and encouragement.

Professional Guidance: Consider working with a certified personal trainer or coach. Professional guidance can help you optimize your training and nutrition plans, ensuring you're on the right track.

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Conclusion

In 2025, bodybuilding is more than just lifting weights; it's a holistic approach to fitness that encompasses technology, nutrition, mental health, and advanced training techniques. By embracing these fitness tips, bodybuilders can achieve their goals, stay injury-free, and enjoy a fulfilling fitness journey. Remember, consistency and dedication are key to success in bodybuilding. Stay committed, keep learning, and most importantly, have fun on your path to becoming the best version of yourself.