Steroids

What is The Extent of Illicit Anabolic Steroid Use in The U.S?

Published

6 years ago

February 3, 2019

Paul

Anabolic Steroids:

Anabolic Steroids substances include male sex dihydrotestosterone and testosterone-hormone. These androgynous hormones promote potent sexual properties development such as voice deepening and growth of beard or other males associated characteristics. These anabolic steroids substances also stimulate additional tissues development, particularly muscle and bone mass, and production of RBCs.

These substances medically used to treat various disorders such as delayed puberty, hypogonadism, osteoporosis, and endometriosis, and other problems that result due to hormonal imbalances.

Anabolic Steroids Prohibition in Sports:

Anabolic steroids that include, for example, Oxandrolone, testosterone, Danabol, and Methyltestosterone agents are used by athletes to enhance performance by increasing muscle mass. The U.S. has prohibited the use of these substances due to their potential for developing adverse side-effects.

The U.S. Agency of Anti-Doping or USADA and Anti-Doping World Agency or WADA and International Committee of Olympic or IOC and National Association Collegiate Athletic or NCAA have included these substances in prohibited-substances lists.

In U.S.A The Limit of Illicit Steroids Use:

In the country of the USA, the street purchase and illegal use of these anabolic steroids substances are risky. Illicit steroids sold at sporting competitions, gyms or through the mail-order process. However, the products may be contaminated or altered products. Records show that these illicit steroid substances that smuggle from other countries or these illegally taken from pharmacies and manufactured in backside laboratories. Street names of these anabolic steroids are Juice, Pumpers, Gym candy, Roids, Andro, and Stackers.

Read More: Where Steroids Are Legal

Anabolic Steroids Abuses:

There is less statistical data available on steroids abuse as; usually, the drug abuse surveys have not included steroids. The scientific evidence from the NIDA institute indicated only ten percent abuse chances among athletes. In the 2017 school Survey, high professionals reported that people do not have an accurate perception of steroids harms. Through laboratory testing, anabolic steroids presence can detect, and athletes monitored for competitions to check drugs usage and dependence.

Side Effects of Anabolic Steroids:

Anabolic steroids use alters body’s healthy balance of hormonal production. Some effects are reversible while some persist such as deepened voice and breast enlargement etc.

Side effects include severe acne, hair loss, liver disease, kidney disease, heart disease, mood swings, high BP, gynecomastia, shrinking testicles, azoospermia, menstrual irregularities, infertility, and bacterial infections.

Anabolic Steroids are Addictive

Users become psychologically and physically dependent. Drug-dependent behavior results due to extended drug use while physical withdrawal problems such as fatigue, mood swings, appetite loss, restlessness, insomnia, steroid cravings, and less sex drive are the consequences. Severe withdrawal issues may cause a high depression level, and even the person can suicide due to high mental pressure. The conditions may persist even after one year of drug stoppage.

Through proper treatments and recovery cycles interventions, anabolic addiction, and anabolic impacts can manage. Antidepressants and analgesics, and behavioral therapies suggest for recovery purposes.

Combat With Anabolic Steroids Use and Abuse:

To limit the use of anabolic steroids, the focus is on educational efforts to promote awareness about steroid abuse. The programs initiated by NIDA such as The ATLAS or Adolescents Learning and Training for Steroids Avoidance, and the ATHENA program or Athletes Targeted Healthy Nutrition and Exercise Alternatives programs. The Health and Science, Oregon University programs, are the focus on teaching athletes about natural bodybuilding.

The programs are about nutrition alternatives and weight-training, healthy behaviors, steroids avoidance, and avoidance of alcoholic use.

Major Steroids Addiction in US Society:

Athletes take high steroids’ doses that lead to health disorders. The increasing use of these substances is a threat to public health. Also, it is essential to quantify the prevalence of Anabolic Steroids use. There are fewer data available on AAS prevalence and use, and these substances have been least studied because these are said as newly introduced substances. However, athletes started to use AAS during the 1950s, and the use increased after 1980s in the US.

The age distribution pattern of Anabolic Steroids users showed that youth is the significant addition or user of steroids since the 1980s. There has been observed a continuous increase in AAS users; however, sparse data has complicated the more accurate prevalence estimations. It requires methodological surveys to access the AAS users and to find the extent of AAS use. Moreover, people hesitate to talk about their steroid experience.

Research evidence

The comparative analyses of AAS users consider in the US context. As the US country is most famous for AAS use, and there are the AAS users in the most significant numbers. The illicit use of anabolic steroids in the US arose before other countries as American culture valued particularly-shaped man figure. U.S movies, dramas, and fitness magazines promoted heroes with bulky and muscular bodies. The US population has the most significant proportion of anabolic steroid users. There have been least surveys conducted on AAS since 1994.

A study revealed that Americans with age group of 13–50 were 108.5 million users that increased to 103.6–113.5 million during 1990–2011.

During the Youth-survey 1991, the data gathered from America’s High-schools revealed that AAS use was every day among 1o^th to 12^th graders. Mathematical models predicted that currently, more than 4.0 M American population depends on AAS.

MTF data shows that young adults of age group 19–28 were AAS users cover 3.1 million of Americans since 1989 to 2011and there was a steady increase in AAS users, while the age group of 19–22 were 3.7 M Americans who were AAS users from 1993 to 2001data estimates. The 2001 survey reported 1.05% lifetime prevalence, and the lifetime steroid prevalence in the US is 2–3 times higher than that was in 1994.

Research studies by Pope et al., and Malone et al., revealed that 2.9 to 4.0M Americans had used anabolic steroids and 1 million among them developed AAS dependence.

Interesting Facts:

Fewer data generate on these aspects because youngsters use this during their 20s time-age and parents don't observe them. Usually, the AAS discussed for athletes, while the vast majority does not belong to competitive athletes groups. Moreover, AAS users did not consult with physicians as the study determined that AAS users about 56% never disclosed about AAS use and the emergence of disorders.
Steroidal supplements modified into testosterone compounds. Steroidal dietary supplements, for example, tetrahydrogestrinone and androstenedione, from food stores without prescription, but their use, now forbidden and illegal after Steroid Control 2004 amendment Act.
Anti-Doping, we also prohibit 3-Dehydroepiandrosterone or (DHEA), but it is legally available. As these agents have fewer effects on performance-enhancement and other detrimental side-effects.

Concluding Notes:

AAS users are still a group of youngsters who rarely develop medical problems of clinical importance; therefore, AAS dependence has remained unnoticed for the most time.
The long-term use of anabolic steroids results in coronary atherosclerosis. Myocardial dysfunction that shows the under-recognized problem of secret steroid use.
Majority of users are recreational weightlifters as compared to competitive athletes who may develop coronary artery and LV dysfunction diseases.

Must Read: What is being done to combat Anabolic Steroids abuse?

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Steroids

Decoding IGF-1 LR3: A Guide to its Benefits

Published

2 weeks ago

April 25, 2025

Sane

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a synthetic variant of IGF-1, a hormone produced by the liver in response to growth hormone (GH). Unlike GH, which works indirectly, IGF-1 directly facilitates the growth and repair of muscle cells.

Related Article: Ostarine for Beginners; The Ultimate Guide

This modified version of IGF-1 is engineered to avoid binding with IGF-binding proteins, extending its half-life to 20–30 hours. As a result, it remains active in the body significantly longer than natural IGF-1.

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Many performance athletes incorporate IGF-1 LR3 post-workout to enhance muscle growth, speed up recovery, and support fat loss. When injected into specific muscle groups, it often produces localized effects. Additionally, it helps with nutrient distribution and, in some cases, improves insulin sensitivity.

On the other hand, human growth hormone (HGH) operates more broadly and indirectly, stimulating the liver to produce IGF-1 and offering more systemic benefits such as improved skin health, joint support, and fat reduction, albeit at a slower pace.

Typical IGF-1 LR3 doses range from 20–50 mcg daily, administered subcutaneously or intramuscularly, often following a workout.

Key Features of IGF-1 LR3

Enhanced Bioavailability: It avoids binding with IGF-binding proteins, increasing its potency.

Muscle Growth & Repair: Directly stimulates muscle cell proliferation and differentiation.

Improved Nutrient Distribution: Helps shuttle nutrients into muscle cells, supporting recovery.

Potential Fat Loss Benefits: Some users report improved insulin sensitivity and fat metabolism.

Mechanism of Action

IGF-1 LR3 interacts with IGF-1 receptors on muscle cells, activating pathways like PI3K-AKT and MAPK, which are crucial for cell growth and regeneration. This makes it a powerful tool for bodybuilders and athletes looking to optimize recovery and muscle development.

What Are the Top 10 Alternatives to IGF-1 LR3?

Here are some of the top alternatives to IGF-1 LR3, each with unique benefits for muscle growth, recovery, and performance:

BPC-157 – Known for its regenerative properties, it enhances healing and tissue repair.

CJC-1295 – A growth hormone-releasing peptide that boosts GH levels for muscle development.

Ipamorelin – Stimulates GH release with minimal side effects, making it a safer option.

MK-677 (Ibutamoren) – A potent GH secretagogue that promotes muscle growth and fat loss.

Sermorelin – Encourages natural GH production, supporting recovery and lean muscle gains.

Tesamorelin – Primarily used for fat loss, but also aids in muscle preservation.

Follistatin-344 – Inhibits myostatin, allowing for increased muscle hypertrophy.

PEG-MGF (Pegylated Mechano Growth Factor) – Enhances muscle repair and growth post-exercise.

GHRP-6 – Stimulates appetite and GH release, supporting muscle mass gains.

GHRP-2 – Similar to GHRP-6 but with fewer hunger-related side effects.

Each of these peptides has distinct mechanisms and benefits.

Must Read: Are Nootropics a Better Option to AAS?

Potential Risks Associated With IGF-1 LR3

IGF-1 LR3 comes with several potential risks, especially for bodybuilders using it to enhance muscle growth. Here are some key concerns:

Hypoglycemia (Low Blood Sugar) – IGF-1 LR3 increases glucose uptake in muscle cells, which can lead to dangerously low blood sugar levels if not managed properly.

Organ Growth – Since IGF-1 affects all tissues, excessive use may lead to unwanted growth in organs, increasing health risks.

Cancer Risk – IGF-1 plays a role in cell proliferation, and elevated levels have been linked to an increased risk of certain cancers.

Water Retention & Edema – Some users experience bloating and fluid retention, which can affect performance and aesthetics.

Joint Pain & Stiffness – Excessive IGF-1 levels may contribute to joint discomfort due to increased tissue growth.

Cardiovascular Issues – There is some concern that IGF-1 LR3 could contribute to heart enlargement or other cardiovascular complications.

Desensitization – Long-term use may reduce the body's natural IGF-1 production, leading to dependency

Overall

IGF-1 LR3's ability to bypass IGF-binding proteins makes it more potent but also increases the likelihood of desensitization with prolonged use. For those considering it, careful dosing and monitoring are crucial to mitigate side effects.

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Steroids

AOD-9604: The Fat-Burning Peptide Explained

Published

1 month ago

April 9, 2025

Sane

AOD-9604, along with the similar HGH Frag 176-191, is a peptide derived from Growth Hormone that includes only the amino acids in HGH responsible for stimulating fat breakdown, known as lipolysis.

This means that these peptides offer the fat-burning benefits of HGH without its other effects—whether beneficial or adverse—and come at a lower cost.

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Lipolysis refers to the process where fat cells are broken down to be utilized as energy. AOD-9604 promotes accelerated fat loss by increasing the body's use of fat as fuel.

For optimal results, the peptides should be used in a fasted state. AOD-9604 and Frag 176-191 are most effective when administered at a dose of 125-250mcg before bedtime (at least 3-4 hours after eating) and in the morning at the same dose, followed by a fasting period of 3-4 hours, ideally combined with fasted cardio.

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Similar Peptides with Fat-Burning Effect

Here’s a list of 10 peptides similar to AOD-9604, each with a brief description:

Ipamorelin: A growth hormone-releasing peptide (GHRP) that stimulates the natural release of growth hormone, promoting fat loss, muscle growth, and improved recovery without affecting other hormones like cortisol or prolactin.

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CJC-1295: A peptide that increases growth hormone and IGF-1 levels, aiding in fat loss, muscle gain, and improved sleep quality. It has a long half-life, making it convenient for users.

HGH Frag 176-191: A fragment of human growth hormone specifically designed for fat-burning. It targets adipose tissue without the broader effects of full-length HGH.

Tesamorelin: Known for reducing visceral fat, this peptide stimulates the release of growth hormone and is often used for weight management and metabolic health.

BPC-157: While primarily known for healing and recovery, BPC-157 can support fat loss indirectly by improving gut health and reducing inflammation.

Melanotan II: Originally developed for skin tanning, it also has appetite-suppressing properties, making it useful for weight management.

Thymosin Beta-4 (TB-500): Focused on healing and recovery, it can enhance physical performance and indirectly support fat loss through improved activity levels.

GHRP-6: A growth hormone-releasing peptide that boosts appetite and metabolism, aiding in muscle growth and fat loss.

Semaglutide: A GLP-1 receptor agonist that regulates appetite and blood sugar levels, making it effective for weight loss and metabolic health.

MK-677 (Ibutamoren): A growth hormone secretagogue that increases growth hormone and IGF-1 levels, promoting fat loss, muscle gain, and improved recovery.

List of Peptides With a Counteractive Effect Bodybuilders Must Avoid

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Some peptides can inadvertently lead to fat gain due to their effects on metabolism and appetite regulation. Here are a few that bodybuilders might want to avoid or use cautiously:

GHRP-6 – While it stimulates growth hormone release, it also significantly increases appetite, which can lead to excess calorie consumption and fat gain.
IGF-1 LR3 – This peptide enhances muscle growth but can also promote fat storage if not carefully managed with diet and training.
MK-677 (Ibutamoren) – Though technically a growth hormone secretagogue rather than a peptide, it boosts GH levels but often leads to increased hunger and potential fat accumulation.
CJC-1295 with DAC – While effective for muscle growth, its prolonged GH release can sometimes lead to unwanted fat retention if not paired with a strict diet

Overall

AOD-9604, derived from Growth Hormone, stimulates fat-burning by targeting lipolysis—the breakdown of fat for energy. It delivers these benefits without the additional effects of Growth Hormone, making it more cost-effective. For maximum effectiveness, it should be administered in a fasted state, ideally before bed and again in the morning at 125-250mcg doses. Pairing its use with fasting and fasted cardio can further enhance fat loss. Its sole focus is on improving the body’s ability to burn fat efficiently.

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Understanding Trenbolone-Induced Cough (“Tren Cough”)

Published

1 month ago

April 7, 2025

Sane

Trenbolone, a potent anabolic steroid, can sometimes cause “tren cough”—a sudden and intense coughing episode shortly after injection. Although not exclusive to Trenbolone, it is more commonly associated with this substance due to its highly irritant nature.

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Mechanisms Behind Tren Cough

Solvent and Carrier Irritation

Trenbolone formulations often include volatile solvents like benzyl alcohol or benzyl benzoate, which may irritate lung tissues when absorbed quickly into systemic circulation.

Prostaglandin Release

Trenbolone promotes increased production of prostaglandins, particularly PGF2α. This compound triggers contraction in the smooth muscles of the lungs, leading to bronchoconstriction and coughing.

Micro-Oil Embolism

Tiny oil droplets from an injection can reach capillaries and travel to the lungs, causing mild embolic reactions that lead to temporary oxygen deprivation and coughing.

Histamine and Mast Cell Activation

For some individuals, Trenbolone triggers histamine release and mast cell activation, mimicking an allergic response and causing bronchospasms and cough reflexes.

Related Article: Best Syringes for Steroid Injection on Amazon

Using Salbutamol (Albuterol) to Manage Tren Cough

Salbutamol, a widely-used β2-adrenergic receptor agonist, can alleviate tren cough symptoms by:
Relaxing bronchial muscles, easing spasms that cause coughing.
Inhibiting prostaglandin effects, reducing bronchoconstriction associated with PGF2α.
Opening airways, preventing severe respiratory restrictions in susceptible individuals.

Application Methods

Inhaler (Optimal)

Take 1–2 puffs of salbutamol (100–200 mcg) 5–10 minutes before a Trenbolone injection. If coughing occurs afterward, additional puffs can swiftly resolve the issue.

Oral Tablets (Moderate)

Consuming 2–4 mg tablets 30–60 minutes before injection offers slower, longer-lasting relief but may be less effective than inhalation methods.

Nebulizer (Severe Cases)

For individuals with frequent episodes, nebulized doses of 2.5 mg salbutamol can provide substantial relief.

Preventive Measures to Reduce Tren Cough Risk

Inject slowly to minimize systemic absorption and irritant effects.
Split doses to lower reaction severity with smaller quantities.
Opt for ventrogluteal injection sites, which have fewer blood vessels, reducing oil embolism risk.
Choose lower-concentration solutions to lessen irritation, as higher concentrations (e.g., Tren Ace 200 mg/ml) are more likely to provoke reactions.

What Other Steroids Can Induce Coughing?

Here's a curated list of peptides, SARMs, and PEDs that may potentially cause coughing or respiratory irritation in bodybuilders and fitness enthusiasts:

Peptides

IGF-1 LR3 (Insulin-like Growth Factor): Known for its anabolic effects, IGF-1 LR3 can occasionally cause mild respiratory irritation due to systemic absorption.

TB-500 (Thymosin Beta-4): While rare, improper injection techniques or high doses may lead to transient coughing episodes.

GHRP-6 (Growth Hormone-Releasing Peptide): This peptide can stimulate histamine release, potentially leading to bronchospasms and coughing.

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SARMs (Selective Androgen Receptor Modulators)

RAD-140: (Testolone) Some users report throat irritation or coughing, often attributed to solvents used in liquid formulations.

YK-11: Known for its myostatin-inhibiting properties, YK-11 may cause mild respiratory discomfort in sensitive individuals.

LGD-4033 (Ligandrol): Though uncommon, some users experience coughing due to carrier solvents or allergic-like reactions.

PEDs (Performance-Enhancing Drugs)

Boldenone Undecylenate (Equipoise): This injectable steroid can cause “Equipoise cough,” similar to tren cough, due to oil embolism or irritant solvents.

Testosterone Suspension: The water-based formulation may lead to coughing episodes if injected improperly or absorbed rapidly.

Nandrolone Decanoate (Deca-Durabolin): While less common, coughing can occur due to histamine release or systemic irritation.

More Tips to Minimize Coughing Risks

Use proper injection techniques to avoid embolic reactions.
Opt for lower-concentration solutions to reduce irritant effects.
Consider antihistamines or bronchodilators for individuals prone to respiratory sensitivity.

Are There Alternatives to Cough-inducing Steroids?

Here are some alternatives to cough-inducing steroids that can provide similar anabolic effects while minimizing respiratory irritation:

Peptides

IGF-1 LR3 (Insulin-like Growth Factor)

Promotes muscle growth and recovery without the irritant properties of certain steroids.

TB-500 (Thymosin Beta-4)

Enhances tissue repair and reduces inflammation, making it a safer option for recovery.

BPC-157 (Body Protection Compound)

Known for its healing properties, it supports muscle repair and joint health.

SARMs (Selective Androgen Receptor Modulators)

RAD-140 (Testolone)

Provides significant muscle-building effects with fewer systemic side effects compared to traditional steroids.

LGD-4033 (Ligandrol)

Boosts lean muscle mass and strength without the risk of respiratory irritation.

MK-677 (Ibutamoren)

Stimulates growth hormone release, aiding in muscle growth and recovery.

Natural Alternatives

Turkesterone

A plant-based ecdysteroid that supports muscle protein synthesis and recovery.

Ecdysterone

Another natural compound that mimics anabolic effects without the harsh side effects.

Creatine Monohydrate

Enhances strength and muscle mass through improved energy production during workouts.

Other Options

Human Growth Hormone (HGH)

Promotes muscle growth and fat loss, though it requires careful monitoring due to potential side effects.

Testosterone Boosters

Natural supplements like D-Aspartic Acid or Tribulus Terrestris can help optimize testosterone levels for muscle growth.

SARMs Alternatives

Legal and safer versions of SARMs are available, offering similar benefits without the risks associated with traditional SARMs.

Overall

We have explored the phenomenon of "tren cough," a sudden, intense coughing episode often caused by Trenbolone injections due to factors like solvent irritation, prostaglandin release, micro-oil embolism, or histamine activation. Preventive measures such as using salbutamol (via inhaler, oral tablets, or nebulizer), injecting slowly, splitting doses, and opting for lower-concentration solutions were highlighted.

Additionally, alternative compounds to tren cough-inducing steroids were discussed, including peptides like IGF-1 LR3 and TB-500, SARMs such as RAD-140 and LGD-4033, and natural options like Turkesterone, ecdysterone, and creatine. These alternatives provide anabolic effects while minimizing respiratory side effects. The conversation also underscored the importance of proper injection techniques and thoughtful compound selection to reduce risks.

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